Functional studies of a H2A.Bbd-like histone variant in mouse spermatogenesis

Impaired DNA demethylation of C/EBP sites causes premature aging

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy.

Heterogeneity of tissue-resident CD8+ T cells in response to infection and malignancy

Hepatic p53 protein level governs liver s sensitivity to drug-induced liver injury

In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

Lipid signalling enforces functional specialization of Treg cells in tumours

Stromal niche inflammation mediated by IL-1 signaling is a targetable driver of hematopoietic aging

Thymic development of type-17 innate-like T cells depends on PTEN

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

SLC38A2 and glutamine signaling in cDC1 dictate anti-tumor immunity

Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer

CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation

Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer

Targeting Vdac2 overcomes immunotherapy resistance by inducing tumor cell death and inflammation

Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells.

Multi-omics analysis identifies erythroid cells as the major immunoregulatory population in mouse placentas

Tracing the derivation of embryonic stem cells from the inner cell mass by single cell RNA-seq analysis

Cohesin-based chromatin interactions enable regulated gene expression within pre-existing architectural compartments.