Heme signaling shifts myeloid differentiation in GM-CSF BM cell cultures

Deviated myeloid differentiation in SCD mice under heme stress I.

Deviated myeloid differentiation in SCD mice under heme stress II.

Targeted erythrophagocyte reprogramming of Kupffer cells halts cancer immunotherapy associated liver toxicity [Ter119 experiment]

Probing cell identity hierarchies by fate titration and collision during direct reprogramming [scRNA-seq & scATAC-seq]

Gene expression profiles at single cell level of lung epithelial cells from the Cracd WT and Cracd KO mice

Red blood cell heme drives the generation of TAM-like macrophages with an immunocompromized phenotype

Control of nutrient uptake by IRF4 orchestrates innate immune memory - scRNA-seq

Red blood cells-heme-exposure and tumor-associated macrophage identity

Age-related epithelial defects limit thymic function and regeneration [visium]

Vancomycin Induced Gut Microbial Dysbiosis Alters Enteric Neuron-Macrophage Interactions During a Critical Period of Postnatal Development

Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm [scRNA-seq]

Orexin/Hypocretin Receptor 2 Signaling in MCH Neurons Regulates REM sleep and Insulin Sensitivity

AireDTR Single Cell

Il7rKO Single Cell

Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity [Mouse_CD45_scRNA]

Virally Encoded Connectivity Transgenic Overlay RNA sequencing (VECTORseq) defines projection neurons involved in sensorimotor integration

Secondary influenza challenge triggers lung resident memory B cell mobilization and rapid relocation for antibody secretion at infected loci

Targeted erythrophagocyte reprogramming of Kupffer cells halts cancer immunotherapy associated liver toxicity

Heme-signaling progresses via NRF2 to educate heme-TAM transformation, tumor cell growth, and invasiveness