CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy.

In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

Lipid signalling enforces functional specialization of Treg cells in tumours

Thymic development of type-17 innate-like T cells depends on PTEN

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology

SLC38A2 and glutamine signaling in cDC1 dictate anti-tumor immunity

Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer

CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation

Targeting Vdac2 overcomes immunotherapy resistance by inducing tumor cell death and inflammation

Distinct Vps34-orchestrated signaling processes dictate the transitional heterogeneity and functional adaptation of effector Treg cells.

CRISPR screening reveals targets to reprogram long-lived effector CD8+ T cells for cancer therapy [scRNA-seq]

In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8+ T cell fate decisions [scRNA-seq]

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq]

Lipid signalling enforces functional specialization of Treg cells in tumours [scRNA-seq EAE]

Metabolic reprogramming of innate-like T cell fate and tissue homeostasis by PTEN [scRNA- and scTCR-seq]

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity [scRNA-seq]

PTEN directs developmental and metabolic signaling for innate-like T cells fate and tissue homeostasis [scRNA-seq and scTCR-seq Exp2]

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq1]

CXCR6 orchestrates brain CD8+ T cell residency and limits mouse Alzheimer’s disease pathology [scRNA-seq2]