Red blood cell heme drives the generation of TAM-like macrophages with an immunocompromized phenotype

Mixed cell-type spheroids endorse the generation and maintenance of heme-TAMs in an experimental tumor microenvironment

Heme-TAMs prevent cancer cell apoptosis and drive growth, invasiveness, and metastasis

Heme-TAMs are resistant to tumoricidal transformation by INFγ

Heme-signaling progresses via NRF2 to educate heme-TAM transformation, tumor cell growth, and invasiveness

Red blood cells-heme-exposure and tumor-associated macrophage identity

Hemorrhage-induced NRF2 signaling in tumor-associated macrophages drives cancer growth, invasion, and immunotherapy resistance