Cdx1 mutant organoid line 1: transduced with Ppard-targetting dual guide RNAs, treated with 4-hydroxytamoxifen

Dual guide RNA targeting Cdx1 infected, untreated, control organoids

Dual guide RNA targeting Ppard infected, untreated, control organoids, 1

Dual guide RNA targeting Ppard infected, untreated, control organoids, 2

Intestinal progenitor cell sample (Human_scRNA-seq)

Intestinal progenitor cell sample (Mouse_scRNA-seq)

Ppard mutant organoid line 1: transduced with Ppard-targetting dual guide RNAs, treated with 4-hydroxytamoxifen, 1

Ppard mutant organoid line 1: transduced with Ppard-targetting dual guide RNAs, treated with 4-hydroxytamoxifen, 2

Total intestinal epithelial cell sample (Human_scRNA-seq)

Total intestinal epithelial cell sample (Mouse_scRNA-seq)

Uninfected, 4-hydroxytamoxifen treated, control organoids

Uninfected, untreated, control organoids

scRNAseq_human_small_intestine_Sample2.1

scRNAseq_human_small_intestine_Sample2.2

scRNAseq_human_small_intestine_Sample2.3

scRNAseq_human_small_intestine_Sample2.4

scRNAseq_human_small_intestine_Sample2.5

scRNAseq_mouse_Diet_1

scRNAseq_mouse_Diet_2

scRNAseq_mouse_Diet_3