Genome

Chlamydia trachomatis Causes disease in either the eye or the urogenital tract Lineage: Bacteria[34407]; Chlamydiae[79]; Chlamydiales[29]; Chlamydiaceae[22]; Chlamydia/Chlamydophila group[18]; Chlamydia[18]; Chlamydia trachomatis[1]

Chlamydiales. Bacteria belonging to the Chlamydiales group are obligate intracellular parasites of eukaryotic cells. They are found within vertebrates, invertebrate cells, and amoebae hosts. In 1999 this group was taxonomically reclassified and it now includes a broader range of Gram-negative bacteria based on their similarities with regards More...to their nucleotide sequences (predominantly ribosomal RNA) and their two-stage developmental cycle of replication (Everett et al., 1999). The Chlamydiales group is now divided into four families, Chlamydiaceae, Simkaniaceae, Parachlamydiaceae and Waddliaceae. The Chlamydiaceae family itself is divided into the genera Chlamydia and Chlamydophila (meaning Chlamydia-like). They have a common evolutionary lineage that started around 2 billion years ago, which makes them unique compared to other types of bacteria. Chlamydiae are one of the commonest causes of sexually transmitted diseases (STDs) and if left untreated may cause infertility in women. They are transmitted by direct contact or aerosols, and can cause various diseases, while also being able to coexist with the host in an apparently asymptomatic state.Chlamydia trachomatis. This species causes infection that leads to blindness and sexually transmitted diseases in humans. There are 15 serovariants that preferentially cause disease in either the eye or the urogenital tract. The trachoma (infection of the mucous membrane of the eyelids) biovars are noninvasive and can cause blinding trachoma (variants A, B, Ba, and C), or sexually transmitted diseases (variants, D, E, F, G, H, I, J, and K). The lymphogranuloma venereum biovars (variants L1, L2, and L3) can cross the epithelial cells of mucous membranes and then travel through the lymphatic system where they multiply within mononuclear phagocytes found within the lymph nodes. Less...

Summary Sequence data:  genome assemblies: 194; sequence reads: 3  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 1.04624  median protein count: 889  median GC%: 41.3 Publications (limited to 20 most recent records) Chlamydia trachomatis: when the virulence-associated genome backbone imports a prevalence-associated major antigen signature. Borges V, et al. Microb Genom 2019 Nov Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense. Fischer A, et al. Elife 2017 Mar 28 Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages. Andersson P, et al. Nat Commun 2016 Feb 25 Low Prevalence of Conjunctival Infection with Chlamydia trachomatis in a Treatment-Naïve Trachoma-Endemic Region of the Solomon Islands. Butcher RM, et al. PLoS Negl Trop Dis 2016 Sep Genomic Investigations unmask Mycoplasma amphoriforme, a new respiratory pathogen. Gillespie SH, et al. Clin Infect Dis 2015 Feb 1 Deep comparative genomics among Chlamydia trachomatis lymphogranuloma venereum isolates highlights genes potentially involved in pathoadaptation. Borges V, et al. Infect Genet Evol 2015 Jun Chlamydia trachomatis In Vivo to In Vitro Transition Reveals Mechanisms of Phase Variation and Down-Regulation of Virulence Factors. Borges V, et al. PLoS One 2015 Draft Genome Sequence of Chlamydia trachomatis Strain 54, Isolated from the Urogenital Tract of a Male in Japan. Yamazaki T, et al. Genome Announc 2015 Oct 22 Plasmid deficiency in urogenital isolates of Chlamydia trachomatis reduces infectivity and virulence in a mouse model. Sigar IM, et al. Pathog Dis 2014 Feb Complete Genome Sequence of Chlamydia trachomatis Ocular Serovar C Strain TW-3. Borges V, et al. Genome Announc 2014 Jan 23 Chlamydia trachomatis clinical isolates identified as tetracycline resistant do not exhibit resistance in vitro: whole-genome sequencing reveals a mutation in porB but no evidence for tetracycline resistance genes. O'Neill CE, et al. Microbiology (Reading) 2013 Apr Whole-genome sequences of Chlamydia trachomatis directly from clinical samples without culture. Seth-Smith HM, et al. Genome Res 2013 May Effect of long-term laboratory propagation on Chlamydia trachomatis genome dynamics. Borges V, et al. Infect Genet Evol 2013 Jul Genomic and phenotypic characterization of in vitro-generated Chlamydia trachomatis recombinants. Jeffrey BM, et al. BMC Microbiol 2013 Jun 20 Culture-independent sequence analysis of Chlamydia trachomatis in urogenital specimens identifies regions of recombination and in-patient sequence mutations. Putman TE, et al. Microbiology (Reading) 2013 Oct Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typing. Harris SR, et al. Nat Genet 2012 Mar 11 Hypervirulent Chlamydia trachomatis clinical strain is a recombinant between lymphogranuloma venereum (L(2)) and D lineages. Somboonna N, et al. mBio 2011 A live-attenuated chlamydial vaccine protects against trachoma in nonhuman primates. Kari L, et al. J Exp Med 2011 Oct 24 Genome sequencing of recent clinical Chlamydia trachomatis strains identifies loci associated with tissue tropism and regions of apparent recombination. Jeffrey BM, et al. Infect Immun 2010 Jun Frameshift mutations in a single novel virulence factor alter the in vivo pathogenicity of Chlamydia trachomatis for the female murine genital tract. Sturdevant GL, et al. Infect Immun 2010 Sep More...  Representative (genome information for reference and representative genomes) Reference genome:   Chlamydia trachomatis D/UW-3/CX Submitter: ChGP Human Pathogen Morphology: Gram:Negative, Shape:Bacilli Environment: OptimumTemperature:37, TemperatureRange:Mesophilic, Habitat:HostAssociated Phenotype: Disease:Pharyngitis, bronchitis and pneumonitis Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NC_000117.1 AE001273.1 1.04 41.3 887 6 37 2 935 3 Dendrogram (based on genomic BLAST)