Genome

Plasmodium vivax (malaria parasite P. vivax) Second most important causal agent of human malaria Lineage: Eukaryota[15557]; Sar[553]; Alveolata[174]; Apicomplexa[80]; Aconoidasida[41]; Haemosporida[23]; Plasmodiidae[22]; Plasmodium[21]; Plasmodium (Plasmodium)[10]; Plasmodium vivax[1]

Plasmodium vivax, the second most important causal agent of human malaria, is the most geographically distributed of the malaria parasites outside Africa (>50% of malaria cases in Asia and in Central and South America), infecting between 130-435 million people every year. P. vivax is responsible for the development of a clinically less More...severe disease than that caused by P. falciparum, and rarely does P.vivax malaria progress to the life-threatening manifestations observed with P.falciparum infections. The clinical differences between the two species are, to a large extent, explained by their different developmental biology and life cycles.The concurrent study of the genomes of these two malaria species will promote the understanding of the parasite biology and the molecular basis of the disease pathology, which in turn should lead to improved design of anti-malaria vaccines and drugs. Less...

Summary Sequence data:  genome assemblies: 18; sequence reads: 174  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 29.1458  median protein count: 6421  median GC%: 39.6833 Publications (limited to 20 most recent records) New Plasmodium vivax Genomes From the China-Myanmar Border. Brashear AM, et al. Front Microbiol 2020 Whole-genome sequencing of a Plasmodium vivax clinical isolate exhibits geographical characteristics and high genetic variation in China-Myanmar border area. Chen SB, et al. BMC Genomics 2017 Feb 6 Genome-wide scans for the identification of Plasmodium vivax genes under positive selection. Shen HM, et al. Malar J 2017 Jun 6 A new Plasmodium vivax reference sequence with improved assembly of the subtelomeres reveals an abundance of pir genes. Auburn S, et al. Wellcome Open Res 2016 Nov 15 Whole-genome sequencing of a Plasmodium vivax isolate from the China-Myanmar border area. Shen HM, et al. Mem Inst Oswaldo Cruz 2015 Sep Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Carlton JM, et al. Nature 2008 Oct 9 Mitochondrial genome sequences support ancient population expansion in Plasmodium vivax. Jongwutiwes S, et al. Mol Biol Evol 2005 Aug The Plasmodium vivax genome sequencing project. Carlton J Trends Parasitol 2003 May Karyotype and synteny among the chromosomes of all four species of human malaria parasite. Carlton JM, et al. Mol Biochem Parasitol 1999 Jun 25 More...  Representative (genome information for reference and representative genomes) Reference genome:   Plasmodium vivax ASM241v2 Submitter: TIGR Loc Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr 1 NC_009906.1 CM000442.1 0.83 47.1 167 2 6 - 176 1 Chr 2 NC_009907.1 CM000443.1 0.76 44.9 154 3 2 2 162 1 Chr 3 NC_009908.2 CM000444.2 1.01 44.9 209 3 5 2 220 1 Chr 4 NC_009909.1 CM000445.1 0.88 45.1 207 - 1 - 208 - Chr 5 NC_009910.1 CM000446.1 1.37 44.3 310 3 - 2 315 - Chr 6 NC_009911.1 CM000447.1 1.03 45.9 244 3 - 1 248 - Chr 7 NC_009912.1 CM000448.1 1.5 45.6 351 - - - 353 2 Chr 8 NC_009913.1 CM000449.1 1.68 45.4 373 2 2 1 379 1 Chr 9 NC_009914.1 CM000450.1 1.92 46.1 432 - 2 - 434 - Chr 10 NC_009915.1 CM000451.1 1.42 45.0 317 3 5 2 327 - Chr 11 NC_009916.1 CM000452.1 2.07 45.1 459 - 9 - 468 - Chr 12 NC_009917.1 CM000453.1 3 44.6 690 - 5 - 695 - Chr 13 NC_009918.1 CM000454.1 2.03 45.7 445 3 1 - 449 - Chr 14 NC_009919.1 CM000455.1 3.12 43.0 691 - 6 - 699 2 MT NC_007243.1 - 0.01 30.5 3 - - - 3 - Un - . - 4.39 28.4 340 - - - 346 6 Chromosomes Click on chromosome name to open Genome Data Viewer External Resources DFCI P.vivax Gene Index GOLD Malaria Foundation Parasite Genome Resources PlasmoDB TIGR The Sanger Institute University of Florida GSS Project WHO/Malaria info WHO/TDR Malaria Database