Genome

Porphyromonas gingivalis Associated with severe and chronic periodontal disease Lineage: Bacteria[34407]; Bacteroidota[3944]; Bacteroidia[1298]; Bacteroidales[1203]; Porphyromonadaceae[206]; Porphyromonas[19]; Porphyromonas gingivalis[1]

Porphyromonas gingivalis.This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and More...eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin.Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases. Proteinases attack extracellular matrix proteins, cell adhesion molecules, and immune system proteins such as cytokines and gamma interferon. Extracellular polysaccharide (capsule) provides protecton against the immune system. Less...

Summary Sequence data:  genome assemblies: 91; sequence reads: 2  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 2.33175  median protein count: 1933  median GC%: 48.4 Publications (limited to 20 most recent records) Molecular basis for avirulence of spontaneous variants of Porphyromonas gingivalis: Genomic analysis of strains W50, BE1 and BR1. Aduse-Opoku J, et al. Mol Oral Microbiol 2022 Jun Diversity analysis of genes encoding Mfa1 fimbrial components in Porphyromonas gingivalis strains. Sakae K, et al. PLoS One 2021 EBI Metagenomics in 2017: enriching the analysis of microbial communities, from sequence reads to assemblies. Mitchell AL, et al. Nucleic Acids Res 2018 Jan 4 Genomic repeats, misassembly and reannotation: a case study with long-read resequencing of Porphyromonas gingivalis reference strains. Acuña-Amador L, et al. BMC Genomics 2018 Jan 16 A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life. Parks DH, et al. Nat Biotechnol 2018 Nov Draft Genome Sequence of Low-Passage Clinical Isolate Porphyromonas gingivalis MP4-504. To TT, et al. Genome Announc 2016 Apr 7 Changes in lipopolysaccharide profile of Porphyromonas gingivalis clinical isolates correlate with changes in colony morphology and polymyxin B resistance. Díaz L, et al. Anaerobe 2015 Jun Genome Sequence of Porphyromonas gingivalis Strain A7436. Chastain-Gross RP, et al. Genome Announc 2015 Sep 24 Draft Genome Sequence of Porphyromonas gingivalis Strain Ando Expressing a 53-Kilodalton-Type Fimbrilin Variant of Mfa1 Fimbriae. Goto T, et al. Genome Announc 2015 Nov 5 Genome Sequence of Porphyromonas gingivalis Strain AJW4. Xie G, et al. Genome Announc 2015 Nov 5 Draft Genome Sequence of Porphyromonas gingivalis Strain SJD2, Isolated from the Periodontal Pocket of a Patient with Periodontitis in China. Liu D, et al. Genome Announc 2014 Jan 2 Genome Sequence of Porphyromonas gingivalis Strain HG66 (DSM 28984). Siddiqui H, et al. Genome Announc 2014 Sep 25 Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. McLean JS, et al. Genome Res 2013 May Complete genome sequence of the bacterium Porphyromonas gingivalis TDC60, which causes periodontal disease. Watanabe T, et al. J Bacteriol 2011 Aug Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis. Naito M, et al. DNA Res 2008 Aug Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83. Nelson KE, et al. J Bacteriol 2003 Sep More...  Representative (genome information for reference and representative genomes) Reference genome:   Porphyromonas gingivalis ATCC 33277 Submitter: Kitasato University Human Pathogen Morphology: Gram:Negative, Shape:Bacilli, Motility:No Environment: OxygenReq:Anaerobic, OptimumTemperature:37, TemperatureRange:Mesophilic, Habitat:HostAssociated Phenotype: Disease:Periodontal disease Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NC_010729.1 AP009380.1 2.35 48.4 1,920 12 53 2 2,059 72 Dendrogram (based on genomic BLAST)