Genome

Mycobacterium ulcerans Causative agent of Buruli and Bairnsdale ulcer Lineage: Bacteria[33718]; Actinobacteria[4335]; Corynebacteriales[654]; Mycobacteriaceae[240]; Mycobacterium[123]; Mycobacterium ulcerans[1]

Mycobacterium ulcerans. Infection by Mycobacterium ulcerans causes the formation of skin ulcers which, if left untreated, can lead to extensive scarring and/or amputation. This disease, called Buruli or Bairnsdale ulcer, is prevalent throughout much of Africa and Asia. Mycobacterium ulcerans produces a cytotoxin, mycolactone, More...which causes the destruction of skin tissue seen in this disease. This organism is resistant to antibiotics and treatment involves the surgical removal of infected tissues. Mycobacterium ulcerans has been identified in stagnant water and in aquatic insects. It is thought that spread of this disease is through contact with water or through the bite of these aquatic insects. Less...

Summary Sequence data:  genome assemblies: 12; sequence reads: 1  (See  Genome Assembly and Annotation report) Statistics:  median total length (Mb): 5.70725  median protein count: 4248  median GC%: 65.5 Publications (limited to 20 most recent records) In Vivo Imaging of Bioluminescent Mycobacterium ulcerans: A Tool to Refine the Murine Buruli Ulcer Tail Model. Omansen TF, et al. Am J Trop Med Hyg 2019 Dec Comparative Genomics Shows That Mycobacterium ulcerans Migration and Expansion Preceded the Rise of Buruli Ulcer in Southeastern Australia. Buultjens AH, et al. Appl Environ Microbiol 2018 Apr 15 On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Doig KD, et al. BMC Genomics 2012 Jun 19 Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Stinear TP, et al. Genome Res 2007 Feb Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans. Stinear TP, et al. Proc Natl Acad Sci U S A 2004 Feb 3 More...  Representative (genome information for reference and representative genomes) Reference genome:   Mycobacterium ulcerans ASM2061661v1 Submitter: University of Melbourne Type Name RefSeq INSDC Size (Mb) GC% Protein rRNA tRNA Other RNA Gene Pseudogene Chr - NZ_CP085200.1 CP085200.1 5.63 65.5 4,207 3 46 3 5,141 882 Plsm pMUM004 NZ_CP085201.1 CP085201.1 0.16 62.8 58 - - - 70 12 Dendrogram (based on genomic BLAST) External Resources BuruList Review