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    Prkdc protein kinase, DNA activated, catalytic polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 19090, updated on 15-Aug-2017
    Official Symbol
    Prkdcprovided by MGI
    Official Full Name
    protein kinase, DNA activated, catalytic polypeptideprovided by MGI
    Primary source
    MGI:MGI:104779
    See related
    Ensembl:ENSMUSG00000022672 Vega:OTTMUSG00000043440
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; AI326420; AU019811; DNA-PKcs
    Orthologs
    Location:
    16 10.09 cM; 16 A2
    Exon count:
    88
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (15637443..15842252)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (15637959..15842332)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene 7748 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene 60S ribosomal protein L30-like Neighboring gene mitotic spindle organizing protein 2 Neighboring gene predicted gene, 41425

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    B cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell receptor V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    V(D)J recombination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    brain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ectopic germ cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    immunoglobulin V(D)J recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of immunoglobulin production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of immune system process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    pro-B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction involved in mitotic G1 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spleen development ISO
    Inferred from Sequence Orthology
    more info
     
    telomere capping ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    DNA-dependent protein kinase-DNA ligase 4 complex ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nonhomologous end joining complex ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    DNA-dependent protein kinase catalytic subunit
    Names
    DNA-PK catalytic subunit
    doxorubicin nephropathy
    severe combined immunodeficiency
    NP_035289.2
    XP_006521924.1
    XP_011244143.1
    XP_011244144.1
    XP_017172381.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011159.2NP_035289.2  DNA-dependent protein kinase catalytic subunit

      See identical proteins and their annotated locations for NP_035289.2

      Status: VALIDATED

      Source sequence(s)
      AB007544, AB011543, AK084827, AK137732, AU019811, CT030649
      Consensus CDS
      CCDS27978.1
      UniProtKB/Swiss-Prot
      P97313
      Related
      ENSMUSP00000023352.7, OTTMUSP00000063630, ENSMUST00000023352.8, OTTMUST00000113952
      Conserved Domains (5) summary
      cd05172
      Location:37194014
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:30243470
      FAT; FAT domain
      pfam02260
      Location:40974128
      FATC; FATC domain
      pfam08163
      Location:18122198
      NUC194; NUC194 domain
      pfam11728
      Location:17661822
      ArAE_1_C; Putative aromatic acid exporter C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      15637443..15842252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521861.3XP_006521924.1  DNA-dependent protein kinase catalytic subunit isoform X1

      Conserved Domains (3) summary
      pfam02259
      Location:30243301
      FAT; FAT domain
      pfam08163
      Location:18122198
      NUC194; NUC194 domain
      pfam11728
      Location:17661822
      ArAE_1_C; Putative aromatic acid exporter C-terminal domain
    2. XM_017316892.1XP_017172381.1  DNA-dependent protein kinase catalytic subunit isoform X2

    3. XM_011245842.2XP_011244144.1  DNA-dependent protein kinase catalytic subunit isoform X4

      Conserved Domains (2) summary
      pfam08163
      Location:18122198
      NUC194; NUC194 domain
      pfam11728
      Location:17661822
      ArAE_1_C; Putative aromatic acid exporter C-terminal domain
    4. XM_011245841.2XP_011244143.1  DNA-dependent protein kinase catalytic subunit isoform X3

      Conserved Domains (5) summary
      cd05172
      Location:20152310
      PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase
      pfam02259
      Location:13201766
      FAT; FAT domain
      pfam02260
      Location:23932424
      FATC; FATC domain
      pfam08163
      Location:108494
      NUC194; NUC194 domain
      pfam11728
      Location:62118
      ArAE_1_C; Putative aromatic acid exporter C-terminal domain
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