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    LOC657351 apoptosis-inducing factor 3 [ Tribolium castaneum (red flour beetle) ]

    Gene ID: 657351, updated on 2-Apr-2025
    Gene symbol
    LOC657351
    Gene description
    apoptosis-inducing factor 3
    Locus tag
    TcasGA2_TC006048
    See related
    EnsemblRapid:LOC657351
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Tribolium castaneum
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
    Orthologs
    fruit fly all
    NEW
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    See LOC657351 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_04 current icTriCast1.1 (GCF_031307605.1) 8 NC_087401.1 (11280924..11287086)
    103 previous assembly Tcas5.2 (GCF_000002335.3) Linkage Group LG8 NC_007423.3 (2470069..2476253, complement)

    Chromosome 8 - NC_087401.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase Wnk Neighboring gene phosphatidylinositol transfer protein vib Neighboring gene ribosomal protein 63, mitochondrial Neighboring gene required for meiotic nuclear division protein 1 homolog Neighboring gene U4 spliceosomal RNA Neighboring gene vacuolar protein sorting-associated protein 33A

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum. Kim HS, et al. Nucleic Acids Res, 2010 Jan. PMID 19820115, Free PMC Article
    2. The genome of the model beetle and pest Tribolium castaneum. Tribolium Genome Sequencing Consortium, et al. Nature, 2008 Apr 24. PMID 18362917
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    apoptosis-inducing factor 3
    Names
    AUGUSTUS-3.0.2_06048
    Apoptosis-inducing factor 3-like Protein
    GLEAN_06048

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference icTriCast1.1 Primary Assembly

    Genomic

    1. NC_087401.1 Reference icTriCast1.1 Primary Assembly

      Range
      11280924..11287086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_963815.5 → XP_968908.2  apoptosis-inducing factor 3 isoform X1

      UniProtKB/TrEMBL
      D6WYS2
      Related
      XP_968908.2, XM_963815.5
      Conserved Domains (4) summary
      cd03478
      Location:60 → 152
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:319 → 402
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:180 → 469
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:499 → 548
      Reductase_C; Reductase C-terminal

    2. XM_008197883.3 → XP_008196105.1  apoptosis-inducing factor 3 isoform X2

      Related
      XP_008196105.1, XM_008197883.3
      Conserved Domains (4) summary
      cd03478
      Location:27 → 119
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:286 → 369
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:147 → 436
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:466 → 515
      Reductase_C; Reductase C-terminal

    3. XM_008197884.3 → XP_008196106.1  apoptosis-inducing factor 3 isoform X3

      Related
      XP_008196106.1, XM_008197884.3
      Conserved Domains (4) summary
      cd03478
      Location:14 → 106
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:273 → 356
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:134 → 423
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:453 → 502
      Reductase_C; Reductase C-terminal

    4. XM_015982289.2 → XP_015837775.1  apoptosis-inducing factor 3 isoform X4

      Related
      XP_015837775.1, XM_015982289.2
      Conserved Domains (4) summary
      cd03478
      Location:1 → 81
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:248 → 331
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:109 → 398
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:428 → 477
      Reductase_C; Reductase C-terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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