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    Ptpmeg Protein tyrosine phosphatase Meg [ Tribolium castaneum (red flour beetle) ]

    Gene ID: 663190, updated on 2-Apr-2025
    Gene symbol
    Ptpmeg
    Gene description
    Protein tyrosine phosphatase Meg
    Locus tag
    TcasGA2_TC005339
    See related
    EnsemblRapid:GeneID_663190
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Tribolium castaneum
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Coleoptera; Polyphaga; Cucujiformia; Tenebrionidae; Tenebrionidae incertae sedis; Tribolium
    Orthologs
    fruit fly all
    NEW
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    See Ptpmeg in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_04 current icTriCast1.1 (GCF_031307605.1) 6 NC_087399.1 (364721..369346)
    103 previous assembly Tcas5.2 (GCF_000002335.3) Linkage Group LG8 NC_007423.3 (14334310..14338692, complement)

    Chromosome 6 - NC_087399.1Genomic Context describing neighboring genes Neighboring gene protein lethal(2)essential for life Neighboring gene alpha-crystallin A chain Neighboring gene methyltransferase-like protein Neighboring gene RNA binding motif single stranded interacting protein alan shepard Neighboring gene uncharacterized LOC107398568 Neighboring gene paired box protein gooseberry

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. BeetleBase in 2010: revisions to provide comprehensive genomic information for Tribolium castaneum. Kim HS, et al. Nucleic Acids Res, 2010 Jan. PMID 19820115, Free PMC Article
    2. The genome of the model beetle and pest Tribolium castaneum. Tribolium Genome Sequencing Consortium, et al. Nature, 2008 Apr 24. PMID 18362917
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    tyrosine-protein phosphatase non-receptor type 4
    Names
    AUGUSTUS-3.0.2_05339
    GLEAN_05339
    Tyrosine-protein phosphatase non-receptor type 4-like Protein

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_031307605.1-RS_2024_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference icTriCast1.1 Primary Assembly

    Genomic

    1. NC_087399.1 Reference icTriCast1.1 Primary Assembly

      Range
      364721..369346
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015982981.2 → XP_015838467.1  tyrosine-protein phosphatase non-receptor type 4 isoform X1

      Related
      XP_015838467.1, XM_015982981.2
      Conserved Domains (8) summary
      smart00194
      Location:621 → 877
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:40 → 237
      B41; Band 4.1 homologues
      cd00047
      Location:648 → 877
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:485 → 571
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:231 → 325
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:130 → 237
      FERM_M; FERM central domain
      pfam08736
      Location:336 → 376
      FA; FERM adjacent (FA)
      pfam09379
      Location:42 → 111
      FERM_N; FERM N-terminal domain

    2. XM_008199239.3 → XP_008197461.1  tyrosine-protein phosphatase non-receptor type 4 isoform X2

      See identical proteins and their annotated locations for XP_008197461.1

      UniProtKB/TrEMBL
      D6WV44
      Related
      XP_008197461.1, XM_008199239.3
      Conserved Domains (8) summary
      smart00194
      Location:615 → 871
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:40 → 237
      B41; Band 4.1 homologues
      cd00047
      Location:642 → 871
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:479 → 565
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:231 → 325
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:130 → 237
      FERM_M; FERM central domain
      pfam08736
      Location:336 → 376
      FA; FERM adjacent (FA)
      pfam09379
      Location:42 → 111
      FERM_N; FERM N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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