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    pbp2x penicillin-binding protein 2X [ Streptococcus mutans UA159 ]

    Gene ID: 1028367, updated on 7-Jul-2018

    Summary

    Gene symbol
    pbp2x
    Gene description
    penicillin-binding protein 2X
    Locus tag
    SMU_455
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Streptococcus mutans UA159 (strain: UA159)
    Lineage
    Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
    Old locus tag
    SMU.455

    Genomic context

    Sequence:
    NC_004350.2 (422739..424988)

    NC_004350.2Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene cell division protein Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene hypothetical protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    • Peptidoglycan biosynthesis, organism-specific biosystem (from KEGG)
      Peptidoglycan biosynthesis, organism-specific biosystemPeptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typica...
    • Peptidoglycan biosynthesis, conserved biosystem (from KEGG)
      Peptidoglycan biosynthesis, conserved biosystemPeptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typica...
    • beta-Lactam resistance, organism-specific biosystem (from KEGG)
      beta-Lactam resistance, organism-specific biosystemThe beta-lactam antibiotics are the most widely used group of antibiotics, which exert their effect by interfering with the structural crosslinking of peptidoglycans in bacterial cell walls. Over the...
    • beta-Lactam resistance, conserved biosystem (from KEGG)
      beta-Lactam resistance, conserved biosystemThe beta-lactam antibiotics are the most widely used group of antibiotics, which exert their effect by interfering with the structural crosslinking of peptidoglycans in bacterial cell walls. Over the...

    General protein information

    Names
    penicillin-binding protein 2X
    NP_720898.1
    • Best Blastp Hit: gb|AAF17264.1|AF210754_1 (AF210754) penicillin-binding protein 2X [Streptococcus pneumoniae]

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004350.2 Reference assembly

      Range
      422739..424988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_720898.1 penicillin-binding protein 2X [Streptococcus mutans UA159]

      See identical proteins and their annotated locations for NP_720898.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q8DVM5
      Conserved Domains (6) summary
      cd06575
      Location:693748
      PASTA_Pbp2x-like_2; PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by ...
      cd06576
      Location:636689
      PASTA_Pbp2x-like_1; PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by ...
      COG0768
      Location:16620
      FtsI; Cell division protein FtsI/penicillin-binding protein 2 [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis]
      sd00037
      Location:637688
      PASTA; PASTA domain [structural motif]
      pfam00905
      Location:290595
      Transpeptidase; Penicillin binding protein transpeptidase domain
      pfam03717
      Location:75246
      PBP_dimer; Penicillin-binding Protein dimerization domain
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