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    SELL selectin L [ Homo sapiens (human) ]

    Gene ID: 6402, updated on 5-Mar-2024

    Summary

    Official Symbol
    SELLprovided by HGNC
    Official Full Name
    selectin Lprovided by HGNC
    Primary source
    HGNC:HGNC:10720
    See related
    Ensembl:ENSG00000188404 MIM:153240; AllianceGenome:HGNC:10720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1
    Summary
    This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
    Expression
    Biased expression in lymph node (RPKM 120.3), spleen (RPKM 87.6) and 5 other tissues See more
    Orthologs
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    Genomic context

    See SELL in Genome Data Viewer
    Location:
    1q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (169690667..169711620, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (169046455..169067407, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (169659808..169680761, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2075 Neighboring gene selectin P Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2076 Neighboring gene uncharacterized LOC107985745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:169636965-169637470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2077 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2078 Neighboring gene selectin E Neighboring gene uncharacterized LOC101928628

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
    EBI GWAS Catalog
    Two new susceptibility loci 1q24.2 and 11p11.2 confer risk to severe acne.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env L-selectin downregulation induced by HIV-1 gp120 is completely reversed by AMD3100 (a CXCR4 antagonist), but not SDF-1 alpha PubMed
    env CD4 ligation by HIV-1 gp120 induces metalloproteinase-dependent L-selectin downregulation in primary resting CD4+ T cells PubMed
    Nef nef HIV-1 Nef mutants L37Q, 62EEEE/AAAA65, P72A/P75A, P78L, and F191A partially impair to downregulate CD62L in Jurkat cells PubMed
    nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of selectin L (CD62L) PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of selectin L (SELL) in primary human brain microvascular endothelial cells PubMed
    Vpu vpu HIV-1 Vpu inhibits the transport of newly synthesized CD62L molecules toward the cell surface of Jurkat cells PubMed
    vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of selectin L (CD62L) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables carbohydrate binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables glycosphingolipid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables heparin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables oligosaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oligosaccharide binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    L-selectin
    Names
    CD62 antigen-like family member L
    gp90-MEL
    leukocyte surface antigen Leu-8
    leukocyte-endothelial cell adhesion molecule 1
    lymph node homing receptor
    lymphocyte adhesion molecule 1
    pln homing receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016132.1 RefSeqGene

      Range
      5083..26036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000655.5NP_000646.3  L-selectin precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
      Source sequence(s)
      AJ246000, BP393094, BQ004720, DA671852
      Consensus CDS
      CCDS53427.2
      UniProtKB/Swiss-Prot
      A0A024R8Z0, B2R6Q8, P14151, P15023, Q9UJ43
      UniProtKB/TrEMBL
      Q8WW79
      Related
      ENSP00000236147.5, ENST00000236147.6
      Conserved Domains (3) summary
      cd00033
      Location:197255
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03592
      Location:39157
      CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
      cd00054
      Location:165192
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RNA

    1. NR_029467.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate 5' exons and has a distinct 5' end compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK298705, AL021940, BC020758, BP393094, CB164568, DC378123

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      169690667..169711620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      169046455..169067407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)