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    PRSS57 serine protease 57 [ Homo sapiens (human) ]

    Gene ID: 400668, updated on 5-Mar-2024

    Summary

    Official Symbol
    PRSS57provided by HGNC
    Official Full Name
    serine protease 57provided by HGNC
    Primary source
    HGNC:HGNC:31397
    See related
    Ensembl:ENSG00000185198 AllianceGenome:HGNC:31397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NSP4; PRSSL1; UNQ782
    Summary
    This gene encodes an arginine-specific serine protease and member of the peptidase S1 family of proteins. The encoded protein may undergo proteolytic activation before storage in azurophil granules, in neutrophil cells of the immune system. Following neutrophil activation, the protease is released into the pericellular environment, where it may play a role in defense against microbial pathogens. [provided by RefSeq, Jul 2016]
    Expression
    Restricted expression toward bone marrow (RPKM 54.0) See more
    Orthologs
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    Genomic context

    Location:
    19p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (685546..695452, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (639634..649468, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (685546..695452, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ring finger protein 126 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:657815-658727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:658728-659641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13568 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9615 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:678746-679248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9617 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:680933-681482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:681483-682031 Neighboring gene follistatin like 3 Neighboring gene ribosomal protein S2 pseudogene 52 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:704097-705067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:707932-708492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:718052-718584 Neighboring gene paralemmin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9621 Neighboring gene mitotic spindle positioning

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General protein information

    Preferred Names
    serine protease 57
    Names
    neutrophil serine protease 4
    protease, serine 57
    serine protease 1-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051189.2 RefSeqGene

      Range
      5000..14906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001308209.2NP_001295138.2  serine protease 57 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC004156, AC112708
      Consensus CDS
      CCDS77203.1
      UniProtKB/TrEMBL
      A0A0A0MR61, B7ZMF6
      Related
      ENSP00000327386.6, ENST00000329267.9
      Conserved Domains (1) summary
      cd00190
      Location:33257
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    2. NM_214710.5NP_999875.2  serine protease 57 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004156, AC112708
      Consensus CDS
      CCDS12041.1
      UniProtKB/Swiss-Prot
      B2RNW8, Q6UWY2
      UniProtKB/TrEMBL
      B7ZMF6
      Related
      ENSP00000482358.1, ENST00000613411.4
      Conserved Domains (1) summary
      cd00190
      Location:34258
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      685546..695452 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      639634..649468 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)