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    RNF14 ring finger protein 14 [ Homo sapiens (human) ]

    Gene ID: 9604, updated on 11-May-2017
    Official Symbol
    RNF14provided by HGNC
    Official Full Name
    ring finger protein 14provided by HGNC
    Primary source
    HGNC:HGNC:10058
    See related
    Ensembl:ENSG00000013561 MIM:605675; Vega:OTTHUMG00000129660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARA54; HFB30; TRIAD2; HRIHFB2038
    Summary
    The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Six alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq, Jan 2011]
    Orthologs
    Location:
    5q31.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (141949337..141993709)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (141346402..141369856)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene KIAA0141 Neighboring gene protocadherin 12 Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene mitochondrial ribosomal protein L11 pseudogene 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ26004

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    androgen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin-like protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase RNF14
    Names
    androgen receptor associated protein 54

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201365.1NP_001188294.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_001188294.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, BC126185, BE042895, DC396586
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Related
      ENSP00000378027.1, ENST00000394519.5
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    2. NM_004290.4NP_004281.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_004281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC402536
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Related
      ENSP00000378028.2, OTTHUMP00000160065, ENST00000394520.6, OTTHUMT00000251860
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    3. NM_183398.2NP_899645.1  E3 ubiquitin-protein ligase RNF14 isoform 2

      See identical proteins and their annotated locations for NP_899645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon compared to variant 1. The translation begins at a downstream start codon and results in an isoform (2) that has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC005740, AF060544, BE042895, DB456366, DC402536
      Consensus CDS
      CCDS4271.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Related
      ENSP00000378022.2, OTTHUMP00000160066, ENST00000394514.6, OTTHUMT00000251861
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
      pfam14634
      Location:94129
      zf-RING_5; zinc-RING finger domain
    4. NM_183399.2NP_899646.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_899646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC396586
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Related
      ENSP00000348462.1, ENST00000356143.5
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    5. NM_183400.2NP_899647.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_899647.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a segment within the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC402536
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Related
      ENSP00000324956.3, ENST00000347642.7
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    6. NM_183401.2NP_899648.1  E3 ubiquitin-protein ligase RNF14 isoform 1

      See identical proteins and their annotated locations for NP_899648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants encode the same isoform (1).
      Source sequence(s)
      AC005740, AF060544, BE042895, DC358984
      Consensus CDS
      CCDS4270.1
      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      141949337..141993709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010076.1XP_016865565.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:479
      RWD; RWD domain
    2. XM_017010070.1XP_016865559.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    3. XM_005268540.3XP_005268597.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      See identical proteins and their annotated locations for XP_005268597.1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
      pfam14634
      Location:94129
      zf-RING_5; zinc-RING finger domain
    4. XM_017010075.1XP_016865564.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:479
      RWD; RWD domain
    5. XM_005268541.3XP_005268598.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      See identical proteins and their annotated locations for XP_005268598.1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
      pfam14634
      Location:94129
      zf-RING_5; zinc-RING finger domain
    6. XM_005268542.2XP_005268599.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      See identical proteins and their annotated locations for XP_005268599.1

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:479
      RWD; RWD domain
    7. XM_005268543.4XP_005268600.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      See identical proteins and their annotated locations for XP_005268600.1

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:479
      RWD; RWD domain
    8. XM_017010077.1XP_016865566.1  E3 ubiquitin-protein ligase RNF14 isoform X4

      UniProtKB/TrEMBL
      B7Z3J5
      Related
      ENSP00000426832.1, OTTHUMP00000222789, ENST00000512565.5, OTTHUMT00000370671
      Conserved Domains (2) summary
      pfam01485
      Location:74130
      IBR; IBR domain, a half RING-finger domain
      cl02687
      Location:448
      RWD; RWD domain
    9. XM_017010073.1XP_016865562.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:479
      RWD; RWD domain
    10. XM_011537714.2XP_011536016.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_011536016.1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    11. XM_005268539.2XP_005268596.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      See identical proteins and their annotated locations for XP_005268596.1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
      pfam14634
      Location:94129
      zf-RING_5; zinc-RING finger domain
    12. XM_005268536.2XP_005268593.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_005268593.1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    13. XM_017010074.1XP_016865563.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      UniProtKB/TrEMBL
      B7Z229
      Conserved Domains (3) summary
      smart00647
      Location:113174
      IBR; In Between Ring fingers
      pfam01485
      Location:201257
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:479
      RWD; RWD domain
    14. XM_005268537.2XP_005268594.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_005268594.1

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (4) summary
      smart00647
      Location:289350
      IBR; In Between Ring fingers
      pfam01485
      Location:377433
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:4133
      RWD; RWD domain
      pfam14634
      Location:220255
      zf-RING_5; zinc-RING finger domain
    15. XM_017010072.1XP_016865561.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
      pfam14634
      Location:94129
      zf-RING_5; zinc-RING finger domain
    16. XM_017010071.1XP_016865560.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/Swiss-Prot
      Q9UBS8
      Conserved Domains (3) summary
      smart00647
      Location:163224
      IBR; In Between Ring fingers
      pfam01485
      Location:251307
      IBR; IBR domain, a half RING-finger domain
      pfam14634
      Location:94129
      zf-RING_5; zinc-RING finger domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      140779739..140803246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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