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    MYEF2 myelin expression factor 2 [ Homo sapiens (human) ]

    Gene ID: 50804, updated on 4-Jun-2017
    Official Symbol
    MYEF2provided by HGNC
    Official Full Name
    myelin expression factor 2provided by HGNC
    Primary source
    HGNC:HGNC:17940
    See related
    Ensembl:ENSG00000104177 Vega:OTTHUMG00000172120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEF-2; MST156; myEF-2; MSTP156; HsT18564
    Orthologs
    Location:
    15q21.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (48134632..48178517, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (48431629..48470714, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370805 Neighboring gene uncharacterized LOC102724553 Neighboring gene uncharacterized LOC107984792 Neighboring gene uncharacterized LOC107984136 Neighboring gene solute carrier family 24 member 5 Neighboring gene uncharacterized LOC105370807 Neighboring gene cortexin 2 Neighboring gene uncharacterized LOC107984756 Neighboring gene solute carrier family 12 member 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Replication interactions

    Interaction Pubs
    Knockdown of myelin expression factor 2 (MYEF2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ11213, KIAA1341, MGC87325

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    myotube differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neuron differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    myelin expression factor 2
    Names
    myelin gene expression factor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301210.1NP_001288139.1  myelin expression factor 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AB037762, AF190159, AK023133, AW023574, BC014533, BX647197, CN358153
      Consensus CDS
      CCDS73722.1
      UniProtKB/Swiss-Prot
      Q9P2K5
      Related
      ENSP00000267836.6, OTTHUMP00000247714, ENST00000267836.10, OTTHUMT00000416979
      Conserved Domains (4) summary
      COG0724
      Location:474576
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:235308
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:101176
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:500576
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    2. NM_016132.4NP_057216.2  myelin expression factor 2 isoform a

      See identical proteins and their annotated locations for NP_057216.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AB037762, AW023574, BX647197, DA680322
      Consensus CDS
      CCDS32230.1
      UniProtKB/Swiss-Prot
      Q9P2K5
      Related
      ENSP00000316950.7, OTTHUMP00000247672, ENST00000324324.11, OTTHUMT00000416909
      Conserved Domains (4) summary
      COG0724
      Location:498600
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:235308
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:101176
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:524600
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    RNA

    1. NR_125408.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' region, and also lacks several 3' exons but includes an alternate 3' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AW964493, BC068523, DA680322
      Related
      ENST00000561351.5, OTTHUMT00000416985

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      48134632..48178517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022287.1XP_016877776.1  myelin expression factor 2 isoform X6

    2. XM_017022285.1XP_016877774.1  myelin expression factor 2 isoform X4

    3. XM_017022286.1XP_016877775.1  myelin expression factor 2 isoform X5

    4. XM_005254425.4XP_005254482.2  myelin expression factor 2 isoform X3

      Conserved Domains (2) summary
      cd12386
      Location:235308
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:101176
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    5. XM_017022292.1XP_016877781.1  myelin expression factor 2 isoform X14

    6. XM_017022291.1XP_016877780.1  myelin expression factor 2 isoform X13

    7. XM_006720553.3XP_006720616.1  myelin expression factor 2 isoform X7

      See identical proteins and their annotated locations for XP_006720616.1

      UniProtKB/TrEMBL
      A0A024R5Q6
      Conserved Domains (4) summary
      COG0724
      Location:338440
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:75148
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12662
      Location:364440
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
      cl17169
      Location:116
      RRM_SF; RNA recognition motif (RRM) superfamily
    8. XM_011521657.2XP_011519959.1  myelin expression factor 2 isoform X8

      Conserved Domains (3) summary
      COG0724
      Location:334436
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:71144
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12662
      Location:360436
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    9. XM_005254422.4XP_005254479.2  myelin expression factor 2 isoform X1

      Conserved Domains (4) summary
      TIGR01628
      Location:124579
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:235308
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:101176
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:507583
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    10. XM_017022290.1XP_016877779.1  myelin expression factor 2 isoform X11

    11. XM_017022288.1XP_016877777.1  myelin expression factor 2 isoform X9

    12. XM_017022289.1XP_016877778.1  myelin expression factor 2 isoform X10

      Conserved Domains (4) summary
      COG0724
      Location:314416
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12386
      Location:75148
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12662
      Location:340416
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
      cl17169
      Location:116
      RRM_SF; RNA recognition motif (RRM) superfamily
    13. XM_005254424.4XP_005254481.2  myelin expression factor 2 isoform X2

      Conserved Domains (4) summary
      TIGR01628
      Location:124555
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:235308
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:101176
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:483559
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    14. XM_005254427.4XP_005254484.1  myelin expression factor 2 isoform X12

      Conserved Domains (2) summary
      cd12386
      Location:235308
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:101176
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      48549817..48588754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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