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    RACK1 receptor for activated C kinase 1 [ Homo sapiens (human) ]

    Gene ID: 10399, updated on 27-Mar-2017
    Official Symbol
    RACK1provided by HGNC
    Official Full Name
    receptor for activated C kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:4399
    See related
    Ensembl:ENSG00000204628 MIM:176981; Vega:OTTHUMG00000163380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H12.3; HLC-7; PIG21; GNB2L1; Gnb2-rs1
    Orthologs
    Location:
    5q35.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (181236928..181243906, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180663928..180671209, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene microRNA 4638 Neighboring gene tripartite motif containing 41 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene uncharacterized LOC101928649 Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene tripartite motif containing 52 Neighboring gene TRIM52 antisense RNA 1 (head to head)

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef The binding of HIV-1 Nef with Rack1 (receptor for activated C kinase 1) is mediated by amino acids 34-143 in Nef; Rack1 acts as a Nef intracellular docking site, bringing Nef and PKCs together PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit beta polypeptide 2-like 1 of G protein (GNB2L1, RACK1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, guanine nucleotide binding protein, beta polypeptide 2-like 1 (GNB2L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    Tat tat Guanine nucleotide binding protein subunit beta polypeptide 2-like 1 (GNB2L1) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    matrix gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SH2 domain binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cysteine-type endopeptidase activator activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ion channel inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex scaffold TAS
    Traceable Author Statement
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase C binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    receptor tyrosine kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signaling adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of hydrogen peroxide-induced neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cAMP catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of ceramide biosynthetic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of cyclic-nucleotide phosphodiesterase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gastrulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein homooligomerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of establishment of cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of tumor necrosis factor-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    rescue of stalled ribosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    IRE1-RACK1-PP2A complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    receptor of activated protein C kinase 1
    Names
    cell proliferation-inducing gene 21 protein
    guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
    guanine nucleotide binding protein beta polypeptide 2-like 1
    guanine nucleotide-binding protein subunit beta-2-like 1
    guanine nucleotide-binding protein subunit beta-like protein 12.3
    human lung cancer oncogene 7 protein
    lung cancer oncogene 7
    proliferation-inducing gene 21
    protein homologous to chicken B complex protein, guanine nucleotide binding
    receptor of activated protein kinase C 1
    small ribosomal subunit protein RACK1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006098.4NP_006089.1  receptor of activated protein C kinase 1

      See identical proteins and their annotated locations for NP_006089.1

      Status: VALIDATED

      Source sequence(s)
      AK222488, BC029996, M24194
      Consensus CDS
      CCDS34324.1
      UniProtKB/Swiss-Prot
      P63244
      UniProtKB/TrEMBL
      E9KL35
      Related
      ENSP00000426909, OTTHUMP00000223704, ENST00000512805, OTTHUMT00000372943
      Conserved Domains (3) summary
      COG2319
      Location:2310
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:7311
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:1861
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      181236928..181243906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      180096332..180103310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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