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    WIPF1 WAS/WASL interacting protein family member 1 [ Homo sapiens (human) ]

    Gene ID: 7456, updated on 6-Aug-2017
    Official Symbol
    WIPF1provided by HGNC
    Official Full Name
    WAS/WASL interacting protein family member 1provided by HGNC
    Primary source
    HGNC:HGNC:12736
    See related
    Ensembl:ENSG00000115935 MIM:602357; Vega:OTTHUMG00000132334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WIP; WAS2; PRPL-2; WASPIP
    Summary
    This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (174559574..174682899, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (175424302..175547667, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene replication protein A3, 14kDa pseudogene Neighboring gene RNA, U6 small nuclear 5, pseudogene Neighboring gene RNA, U7 small nuclear 44 pseudogene Neighboring gene H3 histone, family 3A, pseudogene 4 Neighboring gene cholinergic receptor nicotinic alpha 1 subunit

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
      Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemPhagocytosis is one of the important innate immune responses that function to eliminate invading infectious agents. Monocytes, macrophages, and neutrophils are the professional phagocytic cells. Phag...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
      RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
    • RHO GTPases Activate WASPs and WAVEs, organism-specific biosystem (from REACTOME)
      RHO GTPases Activate WASPs and WAVEs, organism-specific biosystemWASP and WAVE proteins belong to the Wiskott-Aldrich Syndrome protein family, with recessive mutations in the founding member WASP being responsible for the X-linked recessive immunodeficieny known a...
    • Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
      Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemThe actin cytoskeleton is fundamental for phagocytosis and members of the Rho family GTPases RAC and CDC42 are involved in actin cytoskeletal regulation leading to pseudopod extension. Active RAC and...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
      Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC111041

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    profilin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
     
    actin filament-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    actin polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    protein complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    response to other organism IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    actin filament IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    WAS/WASL-interacting protein family member 1
    Names
    WASP-interacting protein
    Wiskott-Aldrich syndrome protein interacting protein
    protein PRPL-2
    testicular tissue protein Li 226

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032009.1 RefSeqGene

      Range
      5001..128326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_374

    mRNA and Protein(s)

    1. NM_001077269.1NP_001070737.1  WAS/WASL-interacting protein family member 1

      See identical proteins and their annotated locations for NP_001070737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA903457, AL529597, AL832275, BC002914, BC045584, BC110288, BM475558, BX640870
      Consensus CDS
      CCDS2260.1
      UniProtKB/Swiss-Prot
      O43516
      UniProtKB/TrEMBL
      A0A140VJZ9, Q2YDC4
      Related
      ENSP00000352802.3, OTTHUMP00000205184, ENST00000359761.7, OTTHUMT00000334133
      Conserved Domains (1) summary
      pfam02205
      Location:3155
      WH2; WH2 motif
    2. NM_003387.4NP_003378.3  WAS/WASL-interacting protein family member 1

      See identical proteins and their annotated locations for NP_003378.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA903457, AL529597, AL832275, BC002914, BC045584, BC110288, BM475558, BX640870, DA674627
      Consensus CDS
      CCDS2260.1
      UniProtKB/Swiss-Prot
      O43516
      UniProtKB/TrEMBL
      A0A140VJZ9, Q2YDC4
      Related
      ENSP00000376330.2, OTTHUMP00000163172, ENST00000392547.6, OTTHUMT00000255453
      Conserved Domains (1) summary
      pfam02205
      Location:3155
      WH2; WH2 motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      174559574..174682899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011511780.2XP_011510082.1  WAS/WASL-interacting protein family member 1 isoform X1

      See identical proteins and their annotated locations for XP_011510082.1

      UniProtKB/Swiss-Prot
      O43516
      UniProtKB/TrEMBL
      A0A140VJZ9
      Related
      ENSP00000376329.2, OTTHUMP00000163178, ENST00000392546.6, OTTHUMT00000255461
      Conserved Domains (1) summary
      pfam02205
      Location:3155
      WH2; WH2 motif

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      175430425..175553733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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