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    ADAR adenosine deaminase, RNA specific [ Homo sapiens (human) ]

    Gene ID: 103, updated on 3-Dec-2017
    Official Symbol
    ADARprovided by HGNC
    Official Full Name
    adenosine deaminase, RNA specificprovided by HGNC
    Primary source
    HGNC:HGNC:225
    See related
    Ensembl:ENSG00000160710 MIM:146920; Vega:OTTHUMG00000037261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSH; AGS6; G1P1; IFI4; P136; ADAR1; DRADA; DSRAD; IFI-4; K88DSRBP
    Summary
    This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 49.6), appendix (RPKM 40.8) and 25 other tissues See more
    Orthologs
    Location:
    1q21.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (154582057..154628016, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154554533..154600456, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985206 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene potassium calcium-activated channel subfamily N member 3 Neighboring gene uncharacterized LOC105371449

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Aicardi-goutieres syndrome 6
    MedGen: C3539013 OMIM: 615010 GeneReviews: Aicardi-Goutieres Syndrome
    Compare labs
    Symmetrical dyschromatosis of extremities
    MedGen: C0406775 OMIM: 127400 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog

    Replication interactions

    Interaction Pubs
    HIV-1 infection (overnight) induces 150-kDa ADAR protein expression in primary human monocyte-derived macrophages BUT NOT in primary CD4+ T cells PubMed
    HIV-1 requires ADAR1 for efficient replication in CD4+ T cells as shown through knockdown and genetic deletion PubMed
    shRNA knockdown of ADAR increases HIV-1 RNA copies in OM10.1 cells (latently infected with HIV-1); HIV is restricted by ADAR PubMed
    HIV-1 is restricted by ADAR in OM10.1 cells (latently infected with HIV-1) overexpressing 150-kDa ADAR PubMed
    siRNA knockdown of ADAR increases HIV-1 replication in monocyte-derived macrophages and alveolar macrophages from HIV-infected patients on antiretroviral therapy (N=4); ADAR restricts HIV-1 replication PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    env ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed
    env Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    env HIV-1 gp120 inhibits adenosine deaminase (ADA) binding to CD26 (dipeptidyl-peptidase 4) in both CD4+ and CD4- cells; this effect requires the interaction of gp120 with CD4 or CXCR4 PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    Pr55(Gag) gag p55 Gag associates with ADAR1 PubMed
    gag Tandem affinity purification and mass spectrometry analysis identify adenosine deaminase RNA-specific binding protein (ADAR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, adenosine deaminase, RNA-specific (ADAR), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with ADAR is increased by RRE PubMed
    rev ADAR1-mediated A-to-G mutations in RRE region of the env gene affect the binding of HIV-1 Rev PubMed
    Tat tat Expression of HIV-1 Tat downregulates the abundance of RNA-specific adenosine deaminase (ADAR) in the nucleoli of Jurkat T-cells PubMed
    capsid gag ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed
    gag Overexpression of ADAR1 increases the levels of gp120, p24, and Nef in HIV-1 producer cells, which requires inhibition of the RNA-activated protein kinase PKR PubMed
    reverse transcriptase gag-pol ADAR1 inhibits HIV-1 viral protein synthesis such as p24 CA, gp120, and p65 Pol proteins in the various cell lines. The catalytic motif of ADAR1 deaminase domain is required for the inhibition function PubMed

    Go to the HIV-1, Human Interaction Database

    • C6 deamination of adenosine, organism-specific biosystem (from REACTOME)
      C6 deamination of adenosine, organism-specific biosystemHydrolytic deamination of adenosine leads to inosine. Ammonia is presumed to be released during this reaction.
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
      Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
    • Formation of editosomes by ADAR proteins, organism-specific biosystem (from REACTOME)
      Formation of editosomes by ADAR proteins, organism-specific biosystemIt is still unclear how ADAR 1 and ADAR 2 proteins form the editosomes with the target RNA. Other components of these editosomes for A to I editing are unknown.
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon alpha/beta signaling, organism-specific biosystem (from REACTOME)
      Interferon alpha/beta signaling, organism-specific biosystemType I interferons (IFNs) are composed of various genes including IFN alpha (IFNA), beta (IFNB), omega, epsilon, and kappa. In humans the IFNA genes are composed of more than 13 subfamily genes, wher...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • mRNA Editing, organism-specific biosystem (from REACTOME)
      mRNA Editing, organism-specific biosystemAfter transcription, some RNA molecules are altered to contain bases not encoded in the genome. Most often this involves the editing or modification of one base to another, but in some organisms can ...
    • mRNA Editing: A to I Conversion, organism-specific biosystem (from REACTOME)
      mRNA Editing: A to I Conversion, organism-specific biosystemIn humans the deamination of adenosines to inosines is the most common editing event. It is particularly prevalent in the brain, where it leads to amino acid changes that affect the conductance of se...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded RNA adenosine deaminase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    double-stranded RNA adenosine deaminase activity TAS
    Traceable Author Statement
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adenosine to inosine editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adenosine to inosine editing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenosine to inosine editing TAS
    Traceable Author Statement
    more info
     
    base conversion or substitution editing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    hematopoietic stem cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA loading onto RISC involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of RNA interference IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase activity by regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of viral genome replication IEA
    Inferred from Electronic Annotation
    more info
     
    osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of viral genome replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic diversification of immune receptors via somatic mutation IEA
    Inferred from Electronic Annotation
    more info
     
    type I interferon signaling pathway TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    supraspliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    double-stranded RNA-specific adenosine deaminase
    Names
    136 kDa double-stranded RNA-binding protein
    adenosine deaminase acting on RNA 1-A
    dsRNA adenosine deaminase
    dsRNA adeonosine deaminase
    interferon-induced protein 4
    interferon-inducible protein 4
    NP_001020278.1
    NP_001102.2
    NP_001180424.1
    NP_056655.2
    NP_056656.2
    XP_006711172.1
    XP_006711174.1
    XP_006711175.1
    XP_006711176.1
    XP_011507362.1
    XP_011507363.2
    XP_011507364.1
    XP_016855526.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011844.1 RefSeqGene

      Range
      24714..50905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025107.2NP_001020278.1  double-stranded RNA-specific adenosine deaminase isoform d

      See identical proteins and their annotated locations for NP_001020278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AA449679, AL592078, BX538232, BX640741, CD108625, DA507408
      Consensus CDS
      CCDS30879.1
      UniProtKB/Swiss-Prot
      P55265
      Related
      ENSP00000357456.3, OTTHUMP00000035373, ENST00000368471.7, OTTHUMT00000090692
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    2. NM_001111.4NP_001102.2  double-stranded RNA-specific adenosine deaminase isoform a

      See identical proteins and their annotated locations for NP_001102.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a, also referred to as ADAR-a).
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, U10439
      Consensus CDS
      CCDS1071.1
      UniProtKB/Swiss-Prot
      P55265
      Related
      ENSP00000357459.4, OTTHUMP00000035372, ENST00000368474.8, OTTHUMT00000090691
      Conserved Domains (3) summary
      smart00358
      Location:504569
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8391222
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:135201
      z-alpha; Adenosine deaminase z-alpha domain
    3. NM_001193495.1NP_001180424.1  double-stranded RNA-specific adenosine deaminase isoform d

      See identical proteins and their annotated locations for NP_001180424.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (d) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, X79448
      Consensus CDS
      CCDS30879.1
      UniProtKB/Swiss-Prot
      P55265
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    4. NM_015840.3NP_056655.2  double-stranded RNA-specific adenosine deaminase isoform b

      See identical proteins and their annotated locations for NP_056655.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b, also referred to as ADAR-b) that is shorter than isoform a. There are no publicly available full-length transcripts representing this variant; it is represented based on data in PMID:9020165 and annotation on DNA accession U75503.1.
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, U10439
      UniProtKB/Swiss-Prot
      P55265
      Related
      ENSP00000431794.1, OTTHUMP00000231779, ENST00000529168.1, OTTHUMT00000387579
      Conserved Domains (3) summary
      smart00358
      Location:504569
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8131196
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:135201
      z-alpha; Adenosine deaminase z-alpha domain
    5. NM_015841.3NP_056656.2  double-stranded RNA-specific adenosine deaminase isoform c

      See identical proteins and their annotated locations for NP_056656.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites in the central coding region, compared to variant 1, resulting in an isoform (c, also referred to as ADAR-c) that is shorter than isoform a. There are no publicly available full-length transcripts representing this variant; it is represented based on data in PMID:9020165 and annotation on DNA accession U75503.1.
      Source sequence(s)
      AA449679, AL592078, AL606500, CD108625, U10439
      UniProtKB/Swiss-Prot
      P55265
      Conserved Domains (3) summary
      smart00358
      Location:504569
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:7941177
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:135201
      z-alpha; Adenosine deaminase z-alpha domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      154582057..154628016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711109.2XP_006711172.1  double-stranded RNA-specific adenosine deaminase isoform X3

      Conserved Domains (3) summary
      smart00358
      Location:514579
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8491232
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:145211
      z-alpha; Adenosine deaminase z-alpha domain
    2. XM_011509060.1XP_011507362.1  double-stranded RNA-specific adenosine deaminase isoform X1

      Conserved Domains (3) summary
      smart00358
      Location:547612
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8821265
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:178244
      z-alpha; Adenosine deaminase z-alpha domain
    3. XM_011509061.2XP_011507363.2  double-stranded RNA-specific adenosine deaminase isoform X2

      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:518901
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    4. XM_011509062.1XP_011507364.1  double-stranded RNA-specific adenosine deaminase isoform X4

      Conserved Domains (3) summary
      smart00358
      Location:510575
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:8451228
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:141207
      z-alpha; Adenosine deaminase z-alpha domain
    5. XM_017000037.1XP_016855526.1  double-stranded RNA-specific adenosine deaminase isoform X2

      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:518901
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    6. XM_006711112.2XP_006711175.1  double-stranded RNA-specific adenosine deaminase isoform X5

      See identical proteins and their annotated locations for XP_006711175.1

      UniProtKB/Swiss-Prot
      P55265
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    7. XM_006711113.2XP_006711176.1  double-stranded RNA-specific adenosine deaminase isoform X5

      See identical proteins and their annotated locations for XP_006711176.1

      UniProtKB/Swiss-Prot
      P55265
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain
    8. XM_006711111.3XP_006711174.1  double-stranded RNA-specific adenosine deaminase isoform X5

      See identical proteins and their annotated locations for XP_006711174.1

      UniProtKB/Swiss-Prot
      P55265
      Conserved Domains (3) summary
      smart00358
      Location:209274
      DSRM; Double-stranded RNA binding motif
      smart00552
      Location:544927
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
      pfam02295
      Location:164
      z-alpha; Adenosine deaminase z-alpha domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      155950933..155996946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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