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    Cul1 Cullin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35742, updated on 4-Feb-2018
    Official Symbol
    Cul1provided by FlyBase
    Official Full Name
    Cullin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015509
    Locus tag
    Dmel_CG1877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1877; cul-1; Cul-1; cul1; CUL1; Cul1[Ex]; Cullin-1; Cullin1; dCul-1; dCul1; dCUL1; dmCUL1; Dmel\CG1877; l(2)02074; l(2)k01207; lin 19; Lin-19; lin-19/cul-1; lin19; Lin19; lin19-like; Q9V312
    Location:
    43F1-43F2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7916856..7921579)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3804361..3809084)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 10 Neighboring gene Diacyl glycerol kinase Neighboring gene CG30377 gene product from transcript CG30377-RB Neighboring gene CG12159 gene product from transcript CG12159-RB Neighboring gene Odorant receptor 43b Neighboring gene Lysine (K)-specific demethylase 4A Neighboring gene CG30381 gene product from transcript CG30381-RB Neighboring gene Major Facilitator Superfamily Transporter 12

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    CONTRIBUTES_TO ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    mitotic G2 DNA damage checkpoint IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IC
    Inferred by Curator
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    SCF ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cullin-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CG1877 gene product from transcript CG1877-RC
    Names
    CG1877-PA
    CG1877-PB
    CG1877-PC
    CG1877-PD
    Cul1-PA
    Cul1-PB
    Cul1-PC
    Cul1-PD
    cullin
    cullin 1
    cullin-1
    cullin1
    dCullin
    dCullin1
    lin-19-like
    lin19-like

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7916856..7921579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165571.2NP_724623.1  cullin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24311
      Related
      FBpp0087921.1, FBtr0088845
      Conserved Domains (3) summary
      smart00182
      Location:454593
      CULLIN; Cullin
      smart00884
      Location:701765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21669
      Cullin; Cullin family
    2. NM_165570.3NP_724622.1  cullin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724622.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24311
      Related
      FBpp0087922.1, FBtr0088846
      Conserved Domains (3) summary
      smart00182
      Location:454593
      CULLIN; Cullin
      smart00884
      Location:701765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21669
      Cullin; Cullin family
    3. NM_165569.2NP_724621.1  cullin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724621.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24311
      Related
      FBpp0087923.1, FBtr0088847
      Conserved Domains (3) summary
      smart00182
      Location:454593
      CULLIN; Cullin
      smart00884
      Location:701765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21669
      Cullin; Cullin family
    4. NM_078931.4NP_523655.1  cullin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523655.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24311
      Related
      FBpp0087924.1, FBtr0088848
      Conserved Domains (3) summary
      smart00182
      Location:454593
      CULLIN; Cullin
      smart00884
      Location:701765
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21669
      Cullin; Cullin family
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