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    gkt glaikit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33530, updated on 9-Jul-2017
    Official Symbol
    gktprovided by FlyBase
    Official Full Name
    glaikitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260817
    Locus tag
    Dmel_CG8825
    Gene type
    protein coding
    RNA name
    glaikit
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-23Db; c22; CG8825; CG8826; Dmel\CG8825; Gkt; Tdp1; TDP1
    Location:
    23D4-23D4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3159950..3162399)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3159950..3162399)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 B subunit Neighboring gene Mothers against dpp Neighboring gene pseudo Neighboring gene alpha/beta hydrolase2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    3'-tyrosyl-DNA phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    3'-tyrosyl-DNA phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    establishment or maintenance of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    single strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    CG8825 gene product from transcript CG8825-RA
    Names
    CG8825-PA
    Tyrosyl-DNA phosophodiesterase 1
    anon-23Db
    gkt-PA
    glaikit

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3159950..3162399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078741.4NP_523465.2  glaikit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523465.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQM4
      Related
      FBpp0077263, FBtr0077574
      Conserved Domains (4) summary
      cd09193
      Location:149317
      PLDc_mTdp1_1; Catalytic domain, repeat 1, of metazoan tyrosyl-DNA phosphodiesterase
      cd09195
      Location:339534
      PLDc_mTdp1_2; Catalytic domain, repeat 2, of metazoan tyrosyl-DNA phosphodiesterase
      pfam06087
      Location:153567
      Tyr-DNA_phospho; Tyrosyl-DNA phosphodiesterase
      pfam10283
      Location:223
      zf-CCHH; Zinc-finger (CX5CX6HX5H) motif
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