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    MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 9223, updated on 5-Nov-2017
    Official Symbol
    MAGI1provided by HGNC
    Official Full Name
    membrane associated guanylate kinase, WW and PDZ domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:946
    See related
    Ensembl:ENSG00000151276 MIM:602625; Vega:OTTHUMG00000157554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19
    Summary
    The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    3p14.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 3 NC_000003.12 (65353525..66038836, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (65339200..66024511, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377127 Neighboring gene long intergenic non-protein coding RNA 2040 Neighboring gene uncharacterized LOC107986094 Neighboring gene uncharacterized LOC105377130 Neighboring gene uncharacterized LOC107986018 Neighboring gene interleukin enhancer binding factor 2 pseudogene 1 Neighboring gene ribosomal protein L17 pseudogene 17 Neighboring gene MAGI1 antisense RNA 1 Neighboring gene uncharacterized LOC105377128 Neighboring gene uncharacterized LOC107986095 Neighboring gene solute carrier family 25 member 26

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
    NHGRI GWA Catalog
    Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
    NHGRI GWA Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog
    • Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystem (from WikiPathways)
      Pathways Affected in Adenoid Cystic Carcinoma, organism-specific biosystemProtein pathways altered by mutations in adenoid cystic carcinoma. Pathways include epigentic modification, DNA damage checkpoint signals, MYB/MYC signalling pathway, FGF/IGF/PI3K signalling, and not...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-actinin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein C-terminus binding TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IDA
    Inferred from Direct Assay
    more info
     
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
    Names
    BAI1-associated protein 1
    WW domain-containing protein 3
    atrophin-1-interacting protein 3
    membrane-associated guanylate kinase inverted 1
    trinucleotide repeat-containing gene 19 protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029778.1 RefSeqGene

      Range
      5001..689604
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001033057.1NP_001028229.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c

      See identical proteins and their annotated locations for NP_001028229.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two segments in the coding region, one of which leads to a frameshift, compared to variant 1. The resulting isoform (c) contains a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC121493, AF401654, AK023358, BC062367
      Consensus CDS
      CCDS33780.1
      UniProtKB/Swiss-Prot
      Q96QZ7
      Related
      ENSP00000385450.2, OTTHUMP00000212270, ENST00000402939.6, OTTHUMT00000349126
      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11231205
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9681062
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361390
      WW; WW domain
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    2. NM_004742.2NP_004733.2  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b

      See identical proteins and their annotated locations for NP_004733.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB010894, AC121493, BC062367
      Consensus CDS
      CCDS2904.1
      UniProtKB/Swiss-Prot
      Q96QZ7
      Related
      ENSP00000420323.1, OTTHUMP00000212272, ENST00000483466.5, OTTHUMT00000349128
      Conserved Domains (6) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11521234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9961091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    3. NM_015520.1NP_056335.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_056335.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (a).
      Source sequence(s)
      AC121493, AF401654, AK023358, BC062367
      Consensus CDS
      CCDS33781.1
      UniProtKB/Swiss-Prot
      Q96QZ7
      Related
      ENSP00000331157.7, OTTHUMP00000212271, ENST00000330909.12, OTTHUMT00000349127
      Conserved Domains (6) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11511233
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9961090
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p7 Primary Assembly

      Range
      65353525..66038836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005265568.1XP_005265625.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X12

      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11391221
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9841078
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349378
      WW; WW domain
      pfam16666
      Location:710793
      MAGI_u5; Unstructured region on MAGI
    2. XM_006713410.1XP_006713473.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X11

      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11401222
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9841079
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:349378
      WW; WW domain
      pfam16666
      Location:710793
      MAGI_u5; Unstructured region on MAGI
    3. XM_005265571.1XP_005265628.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X19

      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10561138
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:819894
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361390
      WW; WW domain
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    4. XM_006713412.1XP_006713475.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14

      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11241206
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9681063
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361390
      WW; WW domain
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    5. XM_005265566.1XP_005265623.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X10

      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11401222
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9961079
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361390
      WW; WW domain
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    6. XM_017007506.1XP_016862995.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X26

    7. XM_017007498.1XP_016862987.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X7

    8. XM_005265564.1XP_005265621.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X5

      See identical proteins and their annotated locations for XP_005265621.1

      UniProtKB/Swiss-Prot
      Q96QZ7
      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11521234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9961091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:361390
      WW; WW domain
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    9. XM_005265574.3XP_005265631.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X23

      Conserved Domains (6) summary
      smart00456
      Location:361392
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11521234
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9961091
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:722805
      MAGI_u5; Unstructured region on MAGI
    10. XM_017007504.1XP_016862993.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X24

    11. XM_006713408.1XP_006713471.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X2

      Conserved Domains (6) summary
      smart00072
      Location:122293
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11531235
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:303332
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9971092
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:362391
      WW; WW domain
      pfam16666
      Location:723806
      MAGI_u5; Unstructured region on MAGI
    12. XM_011534236.1XP_011532538.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X9

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11411223
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9851080
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:350379
      WW; WW domain
      pfam16666
      Location:711794
      MAGI_u5; Unstructured region on MAGI
    13. XM_017007501.1XP_016862990.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X17

    14. XM_017007497.1XP_016862986.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6

    15. XM_017007505.1XP_016862994.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X25

    16. XM_006713409.1XP_006713472.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X3

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11531235
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9971092
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:362391
      WW; WW domain
      pfam16666
      Location:723806
      MAGI_u5; Unstructured region on MAGI
    17. XM_017007502.1XP_016862991.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X21

    18. XM_006713411.1XP_006713474.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X13

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11261208
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9701065
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:363392
      WW; WW domain
      pfam16666
      Location:724807
      MAGI_u5; Unstructured region on MAGI
    19. XM_005265570.1XP_005265627.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X18

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:10861168
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:849924
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:363392
      WW; WW domain
      pfam16666
      Location:724807
      MAGI_u5; Unstructured region on MAGI
    20. XM_005265565.1XP_005265622.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X8

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11421224
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9981081
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:363392
      WW; WW domain
      pfam16666
      Location:724807
      MAGI_u5; Unstructured region on MAGI
    21. XM_005265563.1XP_005265620.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X4

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11531235
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9981092
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:363392
      WW; WW domain
      pfam16666
      Location:724807
      MAGI_u5; Unstructured region on MAGI
    22. XM_017007503.1XP_016862992.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X22

    23. XM_006713407.1XP_006713470.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1

      Conserved Domains (6) summary
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11541236
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9981093
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00397
      Location:363392
      WW; WW domain
      pfam16666
      Location:724807
      MAGI_u5; Unstructured region on MAGI
    24. XM_006713414.3XP_006713477.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X20

      Conserved Domains (6) summary
      smart00456
      Location:363394
      WW; Domain with 2 conserved Trp (W) residues
      smart00072
      Location:122294
      GuKc; Guanylate kinase homologues
      smart00228
      Location:11541236
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00201
      Location:304333
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd00992
      Location:9981093
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:724807
      MAGI_u5; Unstructured region on MAGI
    25. XM_017007499.1XP_016862988.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X15

    26. XM_017007500.1XP_016862989.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X16

    27. XM_017007508.1XP_016862997.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X28

    28. XM_017007507.1XP_016862996.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X27

      Related
      ENSP00000477591.1, ENST00000621418.4
    29. XM_011534240.2XP_011532542.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X29

      Conserved Domains (3) summary
      smart00228
      Location:435517
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:279374
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:1788
      MAGI_u5; Unstructured region on MAGI
    30. XM_011534241.2XP_011532543.1  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X30

      Conserved Domains (3) summary
      smart00228
      Location:407489
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:251346
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam16666
      Location:1788
      MAGI_u5; Unstructured region on MAGI

    Reference GRCh38.p7 PATCHES

    Genomic

    1. NW_012132916.1 Reference GRCh38.p7 PATCHES

      Range
      14787..15634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      65289925..65975909 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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