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    Myef2 myelin basic protein expression factor 2, repressor [ Mus musculus (house mouse) ]

    Gene ID: 17876, updated on 4-Feb-2018
    Official Symbol
    Myef2provided by MGI
    Official Full Name
    myelin basic protein expression factor 2, repressorprovided by MGI
    Primary source
    MGI:MGI:104592
    See related
    Ensembl:ENSMUSG00000027201 Vega:OTTMUSG00000015333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1341; 9430071B01
    Expression
    Broad expression in CNS E11.5 (RPKM 22.6), CNS E14 (RPKM 21.9) and 18 other tissues See more
    Orthologs
    Location:
    2 F1; 2 61.16 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (125080975..125123660, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (124912007..124949396, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34484 Neighboring gene predicted gene, 39920 Neighboring gene solute carrier family 24, member 5 Neighboring gene predicted gene, 46759 Neighboring gene cortexin 2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
      MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
    • Mitochondrial Gene Expression, organism-specific biosystem (from WikiPathways)
      Mitochondrial Gene Expression, organism-specific biosystemNumerous nuclear-encoded genes co-ordinate the expression of genes encoded on the mitochondrial genome.
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    myelin expression factor 2
    Names
    MEF-2
    myEF-2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162417.1NP_001155889.1  myelin expression factor 2 isoform 1

      See identical proteins and their annotated locations for NP_001155889.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK048404, AK143230, BY711324
      Consensus CDS
      CCDS50691.1
      UniProtKB/Swiss-Prot
      Q8C854
      UniProtKB/TrEMBL
      A7UQY4
      Related
      ENSMUSP00000123088.1, OTTMUSP00000043530, ENSMUST00000152367.7, OTTMUST00000036338
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    2. NM_001162418.1NP_001155890.1  myelin expression factor 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the middle portion of the coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK012133, AK143230, AL928902, BB647288, BY711324
      Consensus CDS
      CCDS50689.1
      UniProtKB/TrEMBL
      A2ATP5, A7UQY4
      Related
      ENSMUSP00000114817.1, OTTMUSP00000016329, ENSMUST00000147105.7, OTTMUST00000036340
      Conserved Domains (4) summary
      TIGR01628
      Location:115546
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:474550
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    3. NM_010852.2NP_034982.2  myelin expression factor 2 isoform 2

      See identical proteins and their annotated locations for NP_034982.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the middle portion of the coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK012133, AK143230, AL928902, BB647288, BY711324
      Consensus CDS
      CCDS50690.1
      UniProtKB/TrEMBL
      A7UQY4
      Related
      ENSMUSP00000066312.3, ENSMUST00000067780.9
      Conserved Domains (4) summary
      TIGR01628
      Location:115570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498574
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      125080975..125123660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316131.1XP_017171620.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    2. XM_006498884.3XP_006498947.1  myelin expression factor 2 isoform X2

      See identical proteins and their annotated locations for XP_006498947.1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115570
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:498574
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    3. XM_017316134.1XP_017171623.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
    4. XM_017316132.1XP_017171621.1  myelin expression factor 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8C854
      Conserved Domains (4) summary
      TIGR01628
      Location:115587
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12386
      Location:226299
      RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
      cd12658
      Location:92167
      RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
      cd12662
      Location:515591
      RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

    RNA

    1. XR_001781147.1 RNA Sequence

    2. XR_001781146.1 RNA Sequence

    3. XR_001781149.1 RNA Sequence

    4. XR_001781148.1 RNA Sequence

    5. XR_001781150.1 RNA Sequence

    6. XR_001781152.1 RNA Sequence

    7. XR_001781151.1 RNA Sequence

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