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    CD69 CD69 molecule [ Homo sapiens (human) ]

    Gene ID: 969, updated on 8-May-2017
    Official Symbol
    CD69provided by HGNC
    Official Full Name
    CD69 moleculeprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000110848 MIM:107273; Vega:OTTHUMG00000168481
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26
    This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
    Exon count:
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (9752486..9760901, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (9905082..9913497, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2390 Neighboring gene C-type lectin like 1 Neighboring gene uncharacterized LOC105369653 Neighboring gene germ cell nuclear acidic peptidase pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 significantly inhibits CD69 expression in phytohemagglutinin-stimulated T cells in vitro and may also affect T-cell activation in vivo PubMed
    Nef nef Cells expressing HIV-1 Nef from long-term non-progressors and progressive infection patients induce higher surface levels of CD69 and CD25 than cells producing HIV-2 or SIV Nef PubMed
    nef HIV-1 Nef protein with an intact SH3-binding domain expressed in the productively infected monocyte-derived macrophages is required for the enhanced expression of CD69 on the cell surface PubMed
    nef Functional Nef is required for the activation of resting CD4+ T cells by upregulating CD69 expression on cell surface PubMed
    nef HIV-1 Nef downregulates CD69 in Jurkat cells in a concentration-dependent manner PubMed
    nef HIV-1 Nef blocks a receptor-proximal event in CD3 signaling by downregulating CD69 expression on the cell surface; mutations at amino acid residues P72, P75, R105 and R106 in Nef disrupts the ability of Nef to block CD3 signaling PubMed
    Tat tat HIV-1 Tat binds to a cell surface receptor and activates a cell surface-mediated signal pathway in K562 cells, leading to the activation of NF-kappa B and the induction of CD69 PubMed
    Vpr vpr Human endothelial cell (EC)-stimulated virus-producing cells (p24(high) T cells) are activated to sometimes express CD69 (but not CD25, HLA-DR, VLA-1, or effector cytokines) in the presence of HIV-1 Vpr PubMed

    Go to the HIV-1, Human Interaction Database

    • IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-3 Signaling Pathway, organism-specific biosystemInterleukin 3 (IL-3) is a potent growth factor belonging to the super family of cytokines. IL-3 is a 20- 32kDa glycoprotein involved in the process of hematopoiesis. It is involved in the proliferati...
    Products Interactant Other Gene Complex Source Pubs Description



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    protein binding IPI
    Inferred from Physical Interaction
    more info
    protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    Process Evidence Code Pubs
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
    Component Evidence Code Pubs
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    protein complex IMP
    Inferred from Mutant Phenotype
    more info
    Preferred Names
    early activation antigen CD69
    C-type lectin domain family 2, member C
    CD69 antigen (p60, early T-cell activation antigen)
    activation inducer molecule (AIM/CD69)
    early T-cell activation antigen p60
    early lymphocyte activation antigen
    leukocyte surface antigen Leu-23

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001781.2NP_001772.1  early activation antigen CD69

      See identical proteins and their annotated locations for NP_001772.1

      Status: REVIEWED

      Source sequence(s)
      AC007068, Z22576
      Consensus CDS
      ENSP00000228434.3, OTTHUMP00000238849, ENST00000228434.7, OTTHUMT00000399876
      Conserved Domains (1) summary
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly


    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      9752486..9760901 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1


    1. NC_018923.2 Alternate CHM1_1.1

      9874021..9882437 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_026671.1: Suppressed sequence

      NR_026671.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    2. NR_026672.1: Suppressed sequence

      NR_026672.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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