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    S100A13 S100 calcium binding protein A13 [ Homo sapiens (human) ]

    Gene ID: 6284, updated on 19-May-2018
    Official Symbol
    S100A13provided by HGNC
    Official Full Name
    S100 calcium binding protein A13provided by HGNC
    Primary source
    HGNC:HGNC:10490
    See related
    Ensembl:ENSG00000189171 MIM:601989; Vega:OTTHUMG00000036641
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 156.8), fat (RPKM 39.4) and 16 other tissues See more
    Orthologs
    See S100A13 in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (153618799..153634092, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153591275..153606582, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene S100 calcium binding protein A16 Neighboring gene S100 calcium binding protein A14 Neighboring gene S100 calcium binding protein A1 Neighboring gene chromatin target of PRMT1 Neighboring gene SNAP associated protein Neighboring gene interleukin enhancer binding factor 2 Neighboring gene transfer RNA-iMet (CAT) 1-1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RAGE receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    copper ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-1 alpha secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mast cell degranulation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024210.1NP_001019381.1  protein S100-A13

      See identical proteins and their annotated locations for NP_001019381.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      BC000632, CK817939
      Consensus CDS
      CCDS30874.1
      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    2. NM_001024211.1NP_001019382.1  protein S100-A13

      See identical proteins and their annotated locations for NP_001019382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has a distinct and shorter 5' UTR, as compared to variant 1.
      Source sequence(s)
      BC000632, BM913375
      Consensus CDS
      CCDS30874.1
      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    3. NM_001024212.1NP_001019383.1  protein S100-A13

      See identical proteins and their annotated locations for NP_001019383.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has a distinct and shorter 5' UTR, as compared to variant 1.
      Source sequence(s)
      BC000632, BM762088
      Consensus CDS
      CCDS30874.1
      UniProtKB/Swiss-Prot
      Q99584
      Related
      ENSP00000376399.1, ENST00000392623.5
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    4. NM_001024213.1NP_001019384.1  protein S100-A13

      See identical proteins and their annotated locations for NP_001019384.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has a distinct and shorter 5' UTR, as compared to variant 1.
      Source sequence(s)
      AA366085, BC000632, BX472819
      Consensus CDS
      CCDS30874.1
      UniProtKB/Swiss-Prot
      Q99584
      Related
      ENSP00000376398.1, ENST00000392622.3
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    5. NM_005979.2NP_005970.1  protein S100-A13

      See identical proteins and their annotated locations for NP_005970.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct and shorter 5' UTR, as compared to variant 1.
      Source sequence(s)
      BC000632, BC070291
      Consensus CDS
      CCDS30874.1
      UniProtKB/Swiss-Prot
      Q99584
      Related
      ENSP00000392767.2, ENST00000440685.6
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      153618799..153634092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509863.3XP_011508165.1  protein S100-A13 isoform X1

      See identical proteins and their annotated locations for XP_011508165.1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    2. XM_017002034.2XP_016857523.1  protein S100-A13 isoform X1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    3. XM_017002035.2XP_016857524.1  protein S100-A13 isoform X1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    4. XM_011509862.3XP_011508164.1  protein S100-A13 isoform X1

      See identical proteins and their annotated locations for XP_011508164.1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    5. XM_005245434.3XP_005245491.1  protein S100-A13 isoform X1

      See identical proteins and their annotated locations for XP_005245491.1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    6. XM_011509864.2XP_011508166.1  protein S100-A13 isoform X1

      See identical proteins and their annotated locations for XP_011508166.1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
    7. XM_017002036.1XP_016857525.1  protein S100-A13 isoform X1

      UniProtKB/Swiss-Prot
      Q99584
      Conserved Domains (1) summary
      cd05022
      Location:788
      S-100A13; S-100A13: S-100A13 domain found in proteins similar to S100A13. S100A13 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, ...
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