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    ikzf2 IKAROS family zinc finger 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 100144703, updated on 5-Sep-2025
    Official Symbol
    ikzf2provided by Xenbase
    Official Full Name
    IKAROS family zinc finger 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-1013632
    See related
    Ensembl:ENSXETG00000003127 AllianceGenome:Xenbase:XB-GENE-1013632
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    helios; znf1a2; znfn1a1; znfn1a2
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human IKZF2 (IKAROS family zinc finger 2). [provided by Alliance of Genome Resources, Apr 2025]
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See ikzf2 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 9 NC_030685.2 (57646879..57695023, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 9 NC_030685.1 (52595908..52644038, complement)

    Chromosome 9 - NC_030685.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100493066 Neighboring gene erb-b2 receptor tyrosine kinase 4 Neighboring gene sperm associated antigen 16 Neighboring gene von Willebrand factor C domain containing protein 2 like

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    zinc finger protein Helios

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123458.1 → NP_001116930.1  zinc finger protein Helios

      See identical proteins and their annotated locations for NP_001116930.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161078
      UniProtKB/TrEMBL
      B1H2P4
      Conserved Domains (2) summary
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      57646879..57695023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012970043.3 → XP_012825497.1  zinc finger protein Helios isoform X4

      See identical proteins and their annotated locations for XP_012825497.1

      UniProtKB/TrEMBL
      B1H2P4
      Conserved Domains (2) summary
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    2. XM_012970045.3 → XP_012825499.1  zinc finger protein Helios isoform X6

      UniProtKB/TrEMBL
      A0A8J0SY13
      Conserved Domains (3) summary
      COG5048
      Location:107 → 181
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:116 → 136
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:128 → 153
      zf-H2C2_2; Zinc-finger double domain

    3. XM_012970039.3 → XP_012825493.1  zinc finger protein Helios isoform X1

      See identical proteins and their annotated locations for XP_012825493.1

      UniProtKB/TrEMBL
      F7BPD8
      Conserved Domains (2) summary
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:216 → 241
      zf-H2C2_2; Zinc-finger double domain

    4. XM_012970035.3 → XP_012825489.1  zinc finger protein Helios isoform X1

      See identical proteins and their annotated locations for XP_012825489.1

      UniProtKB/TrEMBL
      F7BPD8
      Related
      ENSXETP00000006785.5, ENSXETT00000006785.5
      Conserved Domains (2) summary
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:216 → 241
      zf-H2C2_2; Zinc-finger double domain

    5. XM_012970044.3 → XP_012825498.1  zinc finger protein Helios isoform X4

      See identical proteins and their annotated locations for XP_012825498.1

      UniProtKB/TrEMBL
      B1H2P4
      Conserved Domains (2) summary
      sd00017
      Location:114 → 134
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:154 → 179
      zf-H2C2_2; Zinc-finger double domain

    6. XM_012970038.3 → XP_012825492.1  zinc finger protein Helios isoform X1

      See identical proteins and their annotated locations for XP_012825492.1

      UniProtKB/TrEMBL
      F7BPD8
      Conserved Domains (2) summary
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:216 → 241
      zf-H2C2_2; Zinc-finger double domain

    7. XM_012970036.3 → XP_012825490.1  zinc finger protein Helios isoform X1

      See identical proteins and their annotated locations for XP_012825490.1

      UniProtKB/TrEMBL
      F7BPD8
      Conserved Domains (2) summary
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:216 → 241
      zf-H2C2_2; Zinc-finger double domain

    8. XM_018097038.2 → XP_017952527.1  zinc finger protein Helios isoform X5

      UniProtKB/TrEMBL
      A0A8J0T5Q5
      Conserved Domains (2) summary
      COG5048
      Location:169 → 483
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_012970040.3 → XP_012825494.1  zinc finger protein Helios isoform X2

      UniProtKB/TrEMBL
      A0A8J0SMS5
      Conserved Domains (3) summary
      COG5048
      Location:169 → 243
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:190 → 215
      zf-H2C2_2; Zinc-finger double domain

    10. XM_018097036.2 → XP_017952525.1  zinc finger protein Helios isoform X3

      UniProtKB/TrEMBL
      A0A803JZU0
      Related
      ENSXETP00000113549.1, ENSXETT00000109317.1
      Conserved Domains (2) summary
      COG5048
      Location:200 → 509
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. XM_031892496.1 → XP_031748356.1  zinc finger protein Helios isoform X1

      UniProtKB/TrEMBL
      F7BPD8
      Conserved Domains (2) summary
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:216 → 241
      zf-H2C2_2; Zinc-finger double domain

    12. XM_018097034.2 → XP_017952523.1  zinc finger protein Helios isoform X1

      UniProtKB/TrEMBL
      F7BPD8
      Conserved Domains (2) summary
      sd00017
      Location:176 → 196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:216 → 241
      zf-H2C2_2; Zinc-finger double domain

    13. XM_012970046.2 → XP_012825500.1  zinc finger protein Helios isoform X7

      UniProtKB/TrEMBL
      A0A8J0SUY3
      Conserved Domains (3) summary
      COG5048
      Location:102 → 200
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:78 → 98
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:118 → 143
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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