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    Mycs myc-like oncogene, s-myc protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24581, updated on 17-Aug-2024

    Summary

    Official Symbol
    Mycsprovided by RGD
    Official Full Name
    myc-like oncogene, s-myc proteinprovided by RGD
    Primary source
    RGD:3133
    See related
    EnsemblRapid:ENSRNOG00000003085 AllianceGenome:RGD:3133
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Feingold syndrome. Orthologous to human MYCN (MYCN proto-oncogene, bHLH transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See Mycs in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (19745887..19747179)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (17038263..17039555)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (17823554..17824846)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene BTB domain containing 35, family member 28 Neighboring gene BTB domain containing 35, family member 9 Neighboring gene ubiquitin-conjugating enzyme E2D 3, pseudogene 1 Neighboring gene spindlin family member 2B like 1

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021837.2NP_068609.2  protein S-Myc

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P23999
      UniProtKB/TrEMBL
      A6KPC7, G3V6D6
      Related
      ENSRNOP00000004118.1, ENSRNOT00000004118.4
      Conserved Domains (2) summary
      cd11456
      Location:344430
      bHLHzip_N-Myc_like; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins
      pfam01056
      Location:10331
      Myc_N; Myc amino-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      19745887..19747179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)