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    scml2 Scm polycomb group protein like 2 [ Oryzias latipes (Japanese medaka) ]

    Gene ID: 101175061, updated on 11-Feb-2026
    Gene symbol
    scml2
    Gene description
    Scm polycomb group protein like 2
    See related
    EnsemblRapid:ENSORLG00000003607
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Oryzias latipes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae; Oryzias
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See scml2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2026_01 current Olatipes_Hd-rR_3.1 (GCF_053564925.1) 3 NC_136239.1 (17327519..17350467)
    103 previous assembly ASM223467v1 (GCF_002234675.1) 3 NC_019861.2 (13997136..14020085)

    Chromosome 3 - NC_136239.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC144990946 Neighboring gene retinoschisin 1a Neighboring gene cyclin dependent kinase like 5 Neighboring gene Nance-Horan syndrome b (congenital cataracts and dental anomalies) Neighboring gene piggyBac transposable element-derived protein 4

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    polycomb protein SCMH1; sex comb on midleg-like protein 2

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_053564925.1-RS_2026_01

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Olatipes_Hd-rR_3.1

    Genomic

    1. NC_136239.1 Reference Olatipes_Hd-rR_3.1

      Range
      17327519..17350467
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011488745.4 → XP_011487047.1  polycomb protein SCMH1 isoform X1

      See identical proteins and their annotated locations for XP_011487047.1

      UniProtKB/TrEMBL
      A0A3P9LEL0, H2LEW7
      Related
      ENSORLP00000046047.1
      Conserved Domains (4) summary
      cd09578
      Location:604 → 675
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:610 → 675
      SAM; Sterile alpha motif
      smart00561
      Location:149 → 240
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:389 → 499
      DUF3588; Protein of unknown function (DUF3588)

    2. XM_011488761.4 → XP_011487063.1  polycomb protein SCMH1 isoform X2

      UniProtKB/TrEMBL
      A0A3P9LEL0
      Related
      ENSORLP00000060872.1
      Conserved Domains (4) summary
      cd09578
      Location:595 → 666
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:601 → 666
      SAM; Sterile alpha motif
      smart00561
      Location:149 → 240
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:381 → 490
      DUF3588; Protein of unknown function (DUF3588)

    3. XM_020712730.3 → XP_020568389.1  sex comb on midleg-like protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A3P9LEL0
      Conserved Domains (4) summary
      cd09578
      Location:559 → 630
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00561
      Location:36 → 131
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam12140
      Location:344 → 454
      SLED; SLED domain
      cl17705
      Location:149 → 198
      MBT; mbt repeat

    4. XM_078944295.1 → XP_078800421.1  polycomb protein SCMH1 isoform X6

    5. XM_078944293.1 → XP_078800419.1  polycomb protein SCMH1 isoform X3

    6. XM_078944294.1 → XP_078800420.1  polycomb protein SCMH1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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