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    smad2 SMAD family member 2 [ Gasterosteus aculeatus (three-spined stickleback) ]

    Gene ID: 120831820, updated on 31-Dec-2025
    Gene symbol
    smad2
    Gene description
    SMAD family member 2
    See related
    Ensembl:ENSGACG00000017820
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gasterosteus aculeatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae; Gasterosteus
    Orthologs
    all
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    Try the new Transcripts and proteins table
    See smad2 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2025_12 current fGasAcu3.hap1.1 (GCF_964276395.1) 14 NC_135702.1 (10981626..10996411)
    100 previous assembly GAculeatus_UGA_version5 (GCF_016920845.1) 14 NC_053225.1 (10019246..10034044)

    Chromosome 14 - NC_135702.1Genomic Context describing neighboring genes Neighboring gene heat shock protein 30-like Neighboring gene N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 Neighboring gene SKI family transcriptional corepressor 2 Neighboring gene immediate early response 3 interacting protein 1

    Go to nucleotide: Graphics FASTA GenBank

    GeneRIFs: Gene References Into Functions

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in activin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    mothers against decapentaplegic homolog 2

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    RefSeqs of Annotated Genomes: GCF_964276395.1-RS_2025_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference fGasAcu3.hap1.1

    Genomic

    1. NC_135702.1 Reference fGasAcu3.hap1.1

      Range
      10981626..10996411
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040197579.2 → XP_040053513.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0AAQ4QRV3, A0AAQ4RFJ2
      Related
      ENSGACP00000052821.1
      Conserved Domains (2) summary
      cd10985
      Location:273 → 463
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
      cl00055
      Location:8 → 179
      MH1; N-terminal Mad Homology 1 (MH1) domain

    2. XM_040197581.2 → XP_040053515.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0AAQ4PSC9, G3Q0Z7
      Related
      ENSGACP00000040918.1
      Conserved Domains (2) summary
      cd10491
      Location:8 → 149
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:243 → 433
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    3. XM_040197580.2 → XP_040053514.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0AAQ4QRV3, A0AAQ4RFJ2
      Conserved Domains (2) summary
      cd10985
      Location:273 → 463
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
      cl00055
      Location:8 → 179
      MH1; N-terminal Mad Homology 1 (MH1) domain
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases