dlx4b distal-less homeobox 4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dlx4bprovided by ZNC
Official Full Name: distal-less homeobox 4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-50
See related: Ensembl:ENSDARG00000071560 AllianceGenome:ZFIN:ZDB-GENE-990415-50
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dlx7; fj03c01; wu:fj03c01; zgc:109858
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; inner ear development; and lens fiber cell differentiation. Predicted to be located in nucleus. Is expressed in several structures, including apical ectodermal ridge pectoral fin bud; ectoderm; inner dental epithelium; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in orofacial cleft 15. Orthologous to human DLX4 (distal-less homeobox 4). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	12	NC_133187.1 (6263282..6272395, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (5719616..5728729, complement)

Chromosome 12 - NC_133187.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.
Title: Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish.
We used antisense morpholino oligonucleotides to target the orthologous Danio rerio gene, dlx4b, and found reduced cranial size and abnormal cartilaginous elements.
Title: DLX4 is associated with orofacial clefting and abnormal jaw development.
the expression and function of hand2 and dlx3b/4b/5a genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches
Title: hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches.
These results provide insight into the mechanisms of preplacodal region (PPR) specification as well as the role of dlx3b/4b function in PPR and otic placode induction.
Title: dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity.
Data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via bone morphogenic protein activity.
Title: dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula.

Submit: New GeneRIF Correction

General gene information

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Markers

DLX7 (e-PCR)
- UniSTS:205364

Z1473 (e-PCR)
- UniSTS:204657

fj03c01.x1 (e-PCR)
- UniSTS:198316

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info
involved_in embryonic morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocrine system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within inner ear receptor cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lens fiber cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic vesicle formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic vesicle morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in system development	IEA Inferred from Electronic Annotation more info
involved_in tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trigeminal nerve development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Dlx4b

Names: DLX-7; distal-less homeobox gene 4b; distal-less homeobox gene 7; distal-less homeobox protein 4b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.