klf3 Kruppel like factor 3 (basic) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: klf3provided by ZNC
Official Full Name: Kruppel like factor 3 (basic)provided by ZNC
Primary source: ZFIN:ZDB-GENE-011116-1
See related: Ensembl:ENSDARG00000015495 AllianceGenome:ZFIN:ZDB-GENE-011116-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: klf12
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and chromatin binding activity. Acts upstream of or within erythrocyte maturation. Is expressed in hatching gland; hematopoietic cell; intermediate cell mass of mesoderm; posterior lateral mesoderm; and pronephric duct. Orthologous to human KLF3 (KLF transcription factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	1	NC_133176.1 (20113935..20135173, complement)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (18594146..18615063, complement)

Chromosome 1 - NC_133176.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb47a07.x1 (e-PCR)
- UniSTS:190596

G45586 (e-PCR)
- UniSTS:106388

G40858 (e-PCR)
- UniSTS:48833

z9886 (e-PCR), detects polymorphism
- UniSTS:205289

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within erythrocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 3

Names: Kruppel-like factor 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.