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    Spn27A Serpin 27A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45815, updated on 9-May-2019

    Summary

    Official Symbol
    Spn27Aprovided by FlyBase
    Official Full Name
    Serpin 27Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028990
    Locus tag
    Dmel_CG11331
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11331; Dm-Spn27A; Dmel\CG11331; EST1; sp27A; Spn27; spn27A; Spn27a

    Genomic context

    See Spn27A in Genome Data Viewer
    Location:
    26F6-26F6; 2-21 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6671065..6673347, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6671065..6673347, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene cup Neighboring gene Galactose-1-phosphate uridylyltransferase Neighboring gene cortex Neighboring gene Non-SMC element 1

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type endopeptidase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanotic encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Toll signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    perivitelline space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    serpin 27A
    Names
    CG11331-PA
    CG11331-PB
    Dm-serpin-27A
    Serpin-27A
    Serpin27A
    Spn27A-PA
    Spn27A-PB

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6671065..6673347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273214.1NP_001260143.1  serpin 27A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260143.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3N1
      Related
      FBpp0305543, FBtr0333351
      Conserved Domains (1) summary
      cd00172
      Location:72440
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
    2. NM_143767.3NP_652024.1  serpin 27A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3N1
      Related
      FBpp0078950, FBtr0079321
      Conserved Domains (1) summary
      cd00172
      Location:72440
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...
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