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    CDC34 cell division cycle 34, ubiqiutin conjugating enzyme [ Homo sapiens (human) ]

    Gene ID: 997, updated on 7-Jul-2024

    Summary

    Official Symbol
    CDC34provided by HGNC
    Official Full Name
    cell division cycle 34, ubiqiutin conjugating enzymeprovided by HGNC
    Primary source
    HGNC:HGNC:1734
    See related
    Ensembl:ENSG00000099804 MIM:116948; AllianceGenome:HGNC:1734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UBC3; UBCH3; UBE2R1; E2-CDC34
    Summary
    The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 23.4), placenta (RPKM 14.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See CDC34 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (531760..542087)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (485161..495858)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (531760..542087)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene MADCAM1 antisense RNA 1 Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:506573-507430 Neighboring gene Sharpr-MPRA regulatory region 4509 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:511078-511918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:511919-512760 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:518458-519364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:531801-532457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:534117-534693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:534694-535269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13563 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:535719-535880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:543421-544066 Neighboring gene granzyme M Neighboring gene CRISPRi-validated cis-regulatory element chr19.73 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:570844-571416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13564 Neighboring gene BSG antisense RNA 1 Neighboring gene basigin (Ok blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif CUL5/RBX2/ELOB/ELOC/Vif/CBF-beta complex catalyzes polyubiquitin chain formation on A3G in the presence of ubiquitin E2 UBE2R1 (CDC34) or UBCH5b (UBE2D2) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication initiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in G1/S transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to interferon-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cAMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of inclusion body assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein modification process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in response to growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 R1
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme R1
    E2 ubiquitin-conjugating enzyme R1
    cell division cycle 34 homolog
    ubiquitin carrier protein
    ubiquitin-conjugating enzyme E2-32 KDA complementing
    ubiquitin-conjugating enzyme E2-CDC34
    ubiquitin-protein ligase R1
    NP_004350.1
    XP_005259747.1
    XP_006723015.1
    XP_054178773.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004359.2NP_004350.1  ubiquitin-conjugating enzyme E2 R1

      See identical proteins and their annotated locations for NP_004350.1

      Status: REVIEWED

      Source sequence(s)
      AC011531, AC011556
      Consensus CDS
      CCDS12030.1
      UniProtKB/Swiss-Prot
      A8K689, P49427
      Related
      ENSP00000215574.2, ENST00000215574.9
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      531760..542087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722952.3XP_006723015.1  ubiquitin-conjugating enzyme E2 R1 isoform X2

      UniProtKB/TrEMBL
      U3KPV8
      Related
      ENSP00000475282.3, ENST00000586283.6
      Conserved Domains (2) summary
      COG5078
      Location:6162
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_005259690.4XP_005259747.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      Conserved Domains (2) summary
      COG5078
      Location:6162
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      485161..495858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322798.1XP_054178773.1  ubiquitin-conjugating enzyme E2 R1 isoform X2

      UniProtKB/TrEMBL
      U3KPV8

    RNA

    1. XR_008485226.1 RNA Sequence