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    USP15 ubiquitin specific peptidase 15 [ Homo sapiens (human) ]

    Gene ID: 9958, updated on 17-Oct-2021

    Summary

    Official Symbol
    USP15provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 15provided by HGNC
    Primary source
    HGNC:HGNC:12613
    See related
    Ensembl:ENSG00000135655 MIM:604731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNPH4; UNPH-2
    Summary
    This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 16.1), appendix (RPKM 8.0) and 24 other tissues See more
    Orthologs
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    Genomic context

    See USP15 in Genome Data Viewer
    Location:
    12q14.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (62260404..62416389)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (62654185..62810169)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TAFA chemokine like family member 2 Neighboring gene ribosomal protein S3 pseudogene 6 Neighboring gene Kruppel like factor 17 pseudogene 1 Neighboring gene microRNA 6125 Neighboring gene RNA, U6 small nuclear 595, pseudogene Neighboring gene MON2 homolog, regulator of endosome-to-Golgi trafficking Neighboring gene RNA, U6 small nuclear 399, pseudogene Neighboring gene long intergenic non-protein coding RNA 1465

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of lung function decline in adults with and without asthma.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ55073, KIAA0529, MGC74854, MGC131982, MGC149838

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 15
    Names
    deubiquitinating enzyme 15
    ubiquitin thioesterase 15
    ubiquitin thiolesterase 15
    ubiquitin-specific-processing protease 15
    NP_001239007.1
    NP_001239008.1
    NP_001338088.1
    NP_001338089.1
    NP_001338090.1
    NP_001338091.1
    NP_001338092.1
    NP_001338093.1
    NP_001338094.1
    NP_001338095.1
    NP_006304.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252078.2NP_001239007.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 1

      See identical proteins and their annotated locations for NP_001239007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC079035, AF153604
      Consensus CDS
      CCDS58251.1
      UniProtKB/Swiss-Prot
      Q9Y4E8
      Related
      ENSP00000280377.5, ENST00000280377.10
      Conserved Domains (1) summary
      COG5560
      Location:12932
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    2. NM_001252079.2NP_001239008.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 3

      See identical proteins and their annotated locations for NP_001239008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and lacks a large portion of the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI027693, BC063454
      Consensus CDS
      CCDS58250.1
      UniProtKB/Swiss-Prot
      Q9Y4E8
      Related
      ENSP00000309240.6, ENST00000312635.10
      Conserved Domains (2) summary
      smart00695
      Location:24121
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:135222
      Ubiquitin_3; Ubiquitin-like domain
    3. NM_001351159.2NP_001338088.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (2) summary
      COG5560
      Location:162811
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      pfam14836
      Location:14101
      Ubiquitin_3; Ubiquitin-like domain
    4. NM_001351160.2NP_001338089.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (1) summary
      COG5560
      Location:34683
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    5. NM_001351161.2NP_001338090.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (1) summary
      smart00695
      Location:24116
      DUSP; Domain in ubiquitin-specific proteases
    6. NM_001351162.2NP_001338091.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC117370
      Conserved Domains (1) summary
      pfam06337
      Location:2775
      DUSP; DUSP domain
    7. NM_001351163.2NP_001338092.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 9-11, encodes isoform 8.
      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (1) summary
      COG5560
      Location:1599
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    8. NM_001351164.2NP_001338093.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 8, 10, and 11, encodes isoform 8.
      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (1) summary
      COG5560
      Location:1599
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    9. NM_001351165.2NP_001338094.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 8, 9, and 11, encodes isoform 8.
      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (1) summary
      COG5560
      Location:1599
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    10. NM_001351166.2NP_001338095.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 8-10, encodes isoform 8.
      Source sequence(s)
      AC048342, AC079035, AC117370
      Conserved Domains (1) summary
      COG5560
      Location:1599
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    11. NM_006313.3NP_006304.1  ubiquitin carboxyl-terminal hydrolase 15 isoform 2

      See identical proteins and their annotated locations for NP_006304.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC079035, AF106069, BC125123, DB451322
      Consensus CDS
      CCDS8963.1
      UniProtKB/Swiss-Prot
      Q9Y4E8
      Related
      ENSP00000258123.4, ENST00000353364.7
      Conserved Domains (1) summary
      COG5560
      Location:12903
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

    RNA

    1. NR_147078.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
    2. NR_147079.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
    3. NR_147080.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
    4. NR_147081.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370
    5. NR_147082.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC048342, AC079035, AC117370

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

      Range
      62260404..62416389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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