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    UBAP2L ubiquitin associated protein 2 like [ Homo sapiens (human) ]

    Gene ID: 9898, updated on 17-Jun-2019

    Summary

    Official Symbol
    UBAP2Lprovided by HGNC
    Official Full Name
    ubiquitin associated protein 2 likeprovided by HGNC
    Primary source
    HGNC:HGNC:29877
    See related
    Ensembl:ENSG00000143569 MIM:616472
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NICE4; NICE-4
    Expression
    Ubiquitous expression in testis (RPKM 26.7), placenta (RPKM 21.3) and 25 other tissues See more
    Orthologs

    Genomic context

    See UBAP2L in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (154220172..154271510)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154192427..154243986)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 190b Neighboring gene chromosome 1 open reading frame 189 Neighboring gene chromosome 1 open reading frame 43 Neighboring gene small nucleolar RNA, H/ACA box 58B Neighboring gene HCLS1 associated protein X-1 Neighboring gene RNA, U6 small nuclear 239, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Cellular biotinylated ubiquitin associated protein 2-like (UBAP2L) is incorporated into HIV-1 Gag virus-like particles PubMed
    Vpr vpr HIV-1 Vpr upregulates UBAP2L in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ42300, KIAA0144

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding HDA PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    binding of sperm to zona pellucida IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hematopoietic stem cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-associated protein 2-like
    Names
    protein NICE-4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127320.2NP_001120792.1  ubiquitin-associated protein 2-like isoform b

      See identical proteins and their annotated locations for NP_001120792.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the UTRs and 3' coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      D63478, DC369803
      Consensus CDS
      CCDS44229.1
      UniProtKB/Swiss-Prot
      Q14157
      Related
      ENSP00000345308.6, ENST00000343815.10
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    2. NM_001287815.1NP_001274744.1  ubiquitin-associated protein 2-like isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the UTRs, uses an alternate in-frame splice site in the central coding region, and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK303533, D63478, DC404293
      Consensus CDS
      CCDS72925.1
      UniProtKB/Swiss-Prot
      Q14157
      Related
      ENSP00000478447.1, ENST00000613315.4
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:489516
      DUF3697; Ubiquitin-associated protein 2
    3. NM_001287816.1NP_001274745.1  ubiquitin-associated protein 2-like isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the central coding region, and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (d) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AJ243670, AK302662, D63478, DC404293
      UniProtKB/Swiss-Prot
      Q14157
      UniProtKB/TrEMBL
      B4DYY5
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    4. NM_001330730.1NP_001317659.1  ubiquitin-associated protein 2-like isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (e) contains an alternate internal segment and has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL590431
      Consensus CDS
      CCDS81381.1
      UniProtKB/TrEMBL
      F8W726
      Related
      ENSP00000271877.8, ENST00000271877.11
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    5. NM_014847.4NP_055662.3  ubiquitin-associated protein 2-like isoform a

      See identical proteins and their annotated locations for NP_055662.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC003170, D63478, DC404293
      Consensus CDS
      CCDS1063.1
      UniProtKB/Swiss-Prot
      Q14157
      Related
      ENSP00000389445.1, ENST00000428931.6
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      154220172..154271510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002976.1XP_016858465.1  ubiquitin-associated protein 2-like isoform X5

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    2. XM_017002986.2XP_016858475.1  ubiquitin-associated protein 2-like isoform X14

      UniProtKB/Swiss-Prot
      Q14157
    3. XM_017002982.2XP_016858471.1  ubiquitin-associated protein 2-like isoform X11

    4. XM_005245672.4XP_005245729.1  ubiquitin-associated protein 2-like isoform X15

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    5. XM_011510216.2XP_011508518.1  ubiquitin-associated protein 2-like isoform X3

      See identical proteins and their annotated locations for XP_011508518.1

      UniProtKB/Swiss-Prot
      Q14157
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    6. XM_017002973.2XP_016858462.1  ubiquitin-associated protein 2-like isoform X4

    7. XM_017002977.2XP_016858466.1  ubiquitin-associated protein 2-like isoform X9

    8. XM_005245674.2XP_005245731.1  ubiquitin-associated protein 2-like isoform X17

      See identical proteins and their annotated locations for XP_005245731.1

      UniProtKB/Swiss-Prot
      Q14157
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    9. XM_005245668.4XP_005245725.1  ubiquitin-associated protein 2-like isoform X7

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    10. XM_005245669.4XP_005245726.1  ubiquitin-associated protein 2-like isoform X8

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    11. XM_005245667.4XP_005245724.1  ubiquitin-associated protein 2-like isoform X5

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    12. XM_005245658.4XP_005245715.1  ubiquitin-associated protein 2-like isoform X1

      See identical proteins and their annotated locations for XP_005245715.1

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    13. XM_011510215.3XP_011508517.1  ubiquitin-associated protein 2-like isoform X2

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    14. XM_017002975.2XP_016858464.1  ubiquitin-associated protein 2-like isoform X6

    15. XM_005245673.4XP_005245730.1  ubiquitin-associated protein 2-like isoform X16

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    16. XM_024451291.1XP_024307059.1  ubiquitin-associated protein 2-like isoform X18

      Conserved Domains (1) summary
      pfam12478
      Location:266293
      DUF3697; Ubiquitin-associated protein 2
    17. XM_017002983.1XP_016858472.1  ubiquitin-associated protein 2-like isoform X12

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    18. XM_017002987.1XP_016858476.1  ubiquitin-associated protein 2-like isoform X14

      UniProtKB/Swiss-Prot
      Q14157
    19. XM_017002984.1XP_016858473.1  ubiquitin-associated protein 2-like isoform X11

    20. XM_017002988.1XP_016858477.1  ubiquitin-associated protein 2-like isoform X15

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    21. XM_017002978.1XP_016858467.1  ubiquitin-associated protein 2-like isoform X10

      UniProtKB/Swiss-Prot
      Q14157
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    22. XM_017002974.1XP_016858463.1  ubiquitin-associated protein 2-like isoform X4

    23. XM_017002980.2XP_016858469.1  ubiquitin-associated protein 2-like isoform X9

    24. XM_017002989.1XP_016858478.1  ubiquitin-associated protein 2-like isoform X17

      UniProtKB/Swiss-Prot
      Q14157
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    25. XM_017002985.2XP_016858474.1  ubiquitin-associated protein 2-like isoform X13

      UniProtKB/TrEMBL
      F8W726
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    26. XM_017002972.2XP_016858461.1  ubiquitin-associated protein 2-like isoform X2

      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:507534
      DUF3697; Ubiquitin-associated protein 2
    27. XM_017002979.1XP_016858468.1  ubiquitin-associated protein 2-like isoform X10

      UniProtKB/Swiss-Prot
      Q14157
      Related
      ENSP00000355343.2, ENST00000361546.6
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
    28. XM_017002981.2XP_016858470.1  ubiquitin-associated protein 2-like isoform X9

    29. XM_017002990.1XP_016858479.1  ubiquitin-associated protein 2-like isoform X17

      UniProtKB/Swiss-Prot
      Q14157
      Conserved Domains (2) summary
      cd14277
      Location:5087
      UBA_UBP2_like; UBA domain found in ubiquitin-associated protein 2 (UBAP-2) like proteins
      pfam12478
      Location:496523
      DUF3697; Ubiquitin-associated protein 2
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