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    MRPL19 mitochondrial ribosomal protein L19 [ Homo sapiens (human) ]

    Gene ID: 9801, updated on 17-Jun-2019

    Summary

    Official Symbol
    MRPL19provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L19provided by HGNC
    Primary source
    HGNC:HGNC:14052
    See related
    Ensembl:ENSG00000115364 MIM:611832
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RLX1; L19mt; MRPL15; RPML15; MRP-L15; MRP-L19
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.4), kidney (RPKM 7.1) and 25 other tissues See more
    Orthologs

    Genomic context

    See MRPL19 in Genome Data Viewer
    Location:
    2p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (75646783..75662206)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (75873909..75889334)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 57 Neighboring gene uncharacterized LOC101927884 Neighboring gene eva-1 homolog A, regulator of programmed cell death Neighboring gene Sharpr-MPRA regulatory region 13771 Neighboring gene SPT4 homolog, DSIF elongation factor subunit pseudogene Neighboring gene uncharacterized LOC105374813 Neighboring gene GC-rich sequence DNA-binding factor 2 Neighboring gene succinate-CoA ligase ADP-forming beta subunit pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    NHGRI GWA Catalog

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0104, MGC20675

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    mitochondrial translational elongation TAS
    Traceable Author Statement
    more info
     
    mitochondrial translational termination TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    39S ribosomal protein L19, mitochondrial
    Names
    39S ribosomal protein L15, mitochondrial
    L15mt
    mitochondrial large ribosomal subunit protein bL19m

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014763.4NP_055578.2  39S ribosomal protein L19, mitochondrial

      See identical proteins and their annotated locations for NP_055578.2

      Status: REVIEWED

      Source sequence(s)
      AC005034, BQ432684
      Consensus CDS
      CCDS1960.2
      UniProtKB/Swiss-Prot
      P49406
      Related
      ENSP00000377486.2, ENST00000393909.7
      Conserved Domains (1) summary
      cl00406
      Location:108192
      Ribosomal_L19; Ribosomal protein L19

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      75646783..75662206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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