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    SERTAD2 SERTA domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 9792, updated on 17-Jun-2019

    Summary

    Official Symbol
    SERTAD2provided by HGNC
    Official Full Name
    SERTA domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30784
    See related
    Ensembl:ENSG00000179833 MIM:617851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Sei-2; TRIPBR2; TRIP-Br2
    Expression
    Ubiquitous expression in bone marrow (RPKM 29.6), esophagus (RPKM 11.9) and 24 other tissues See more
    Orthologs

    Genomic context

    See SERTAD2 in Genome Data Viewer
    Location:
    2p14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (64631621..64751086, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (64858755..64978048, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aftiphilin Neighboring gene uncharacterized LOC105374772 Neighboring gene long intergenic non-protein coding RNA 2579 Neighboring gene uncharacterized LOC105374775 Neighboring gene ribosomal protein S10 pseudogene 9 Neighboring gene uncharacterized LOC105374777 Neighboring gene uncharacterized LOC105374776

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC126688, MGC126690

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    SERTA domain-containing protein 2
    Names
    transcriptional regulator interacting with the PHD-bromodomain 2
    transcriptional regulator interacting with the PHS-bromodomain 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014755.3NP_055570.1  SERTA domain-containing protein 2

      See identical proteins and their annotated locations for NP_055570.1

      Status: VALIDATED

      Source sequence(s)
      AC007365, BQ017415
      Consensus CDS
      CCDS33210.1
      UniProtKB/Swiss-Prot
      Q14140
      Related
      ENSP00000326933.3, ENST00000313349.3
      Conserved Domains (1) summary
      pfam06031
      Location:4077
      SERTA; SERTA motif

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      64631621..64751086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264669.3XP_005264726.1  SERTA domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_005264726.1

      UniProtKB/Swiss-Prot
      Q14140
      Conserved Domains (1) summary
      pfam06031
      Location:4077
      SERTA; SERTA motif
    2. XM_011533205.2XP_011531507.1  SERTA domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011531507.1

      UniProtKB/Swiss-Prot
      Q14140
      Conserved Domains (1) summary
      pfam06031
      Location:4077
      SERTA; SERTA motif
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