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    ARHGAP32 Rho GTPase activating protein 32 [ Homo sapiens (human) ]

    Gene ID: 9743, updated on 8-Jul-2021

    Summary

    Official Symbol
    ARHGAP32provided by HGNC
    Official Full Name
    Rho GTPase activating protein 32provided by HGNC
    Primary source
    HGNC:HGNC:17399
    See related
    Ensembl:ENSG00000134909 MIM:608541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
    Summary
    RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARHGAP32 in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (128965060..129279518, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128834955..129149413, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNJ5 antisense RNA 1 Neighboring gene potassium inwardly rectifying channel subfamily J member 5 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene RNA, U6 small nuclear 876, pseudogene Neighboring gene RNA, U6 small nuclear 874, pseudogene Neighboring gene uncharacterized LOC399975 Neighboring gene HNF4 motif-containing MPRA enhancer 230 Neighboring gene uncharacterized LOC105369571 Neighboring gene zinc finger protein 123, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    GeneReviews: Not available

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC1892, KIAA0712

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    enables phosphatidylinositol phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in fibrillar center IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 32
    Names
    GAB-associated CDC42
    GAB-associated Cdc42/Rac GTPase-activating protein
    GTPase regulator interacting with TrkA
    GTPase-activating protein for Cdc42 and Rac1
    RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
    brain-specific Rho GTP-ase-activating protein
    brain-specific Rho GTPase-activating protein
    rac GTPase activating protein
    rho-type GTPase-activating protein 32
    rho/Cdc42/Rac GTPase-activating protein RICS
    rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142685.2NP_001136157.1  rho GTPase-activating protein 32 isoform 1

      See identical proteins and their annotated locations for NP_001136157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). This isoform is also known as PX-RICS.
      Source sequence(s)
      AP000747, AP000751, AP002886
      Consensus CDS
      CCDS44769.1
      UniProtKB/Swiss-Prot
      A7KAX9
      UniProtKB/TrEMBL
      Q86T64
      Related
      ENSP00000310561.8, ENST00000310343.13
      Conserved Domains (3) summary
      cd07298
      Location:127241
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:263316
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:368562
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    2. NM_001378024.1NP_001364953.1  rho GTPase-activating protein 32 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AP000747, AP000751, AP002886
      Related
      ENSP00000507720.1, ENST00000682385.1
      Conserved Domains (3) summary
      cd07298
      Location:141255
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:277330
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:382576
      RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
    3. NM_001378025.1NP_001364954.1  rho GTPase-activating protein 32 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AP000747, AP000751, AP002886
      Conserved Domains (3) summary
      cd07298
      Location:87201
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:223276
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:328522
      RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...
    4. NM_014715.4NP_055530.2  rho GTPase-activating protein 32 isoform 2

      See identical proteins and their annotated locations for NP_055530.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.
      Source sequence(s)
      AB079856, AP000751, BQ319051, EF127492
      Consensus CDS
      CCDS31718.1
      UniProtKB/Swiss-Prot
      A7KAX9
      Related
      ENSP00000376425.3, ENST00000392657.7
      Conserved Domains (1) summary
      cd04384
      Location:19213
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      128965060..129279518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018595.2XP_016874084.1  rho GTPase-activating protein 32 isoform X3

      Conserved Domains (3) summary
      cd07298
      Location:101215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342536
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    2. XM_011543072.2XP_011541374.1  rho GTPase-activating protein 32 isoform X3

      See identical proteins and their annotated locations for XP_011541374.1

      Conserved Domains (3) summary
      cd07298
      Location:101215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342536
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    3. XM_011543073.2XP_011541375.2  rho GTPase-activating protein 32 isoform X2

    4. XM_017018596.1XP_016874085.1  rho GTPase-activating protein 32 isoform X4

    5. XM_011543075.2XP_011541377.1  rho GTPase-activating protein 32 isoform X5

      Conserved Domains (1) summary
      cd04384
      Location:43237
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...
    6. XM_017018597.2XP_016874086.1  rho GTPase-activating protein 32 isoform X6

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