Format

Send to:

Choose Destination
    • Showing Current items.

    HDAC9 histone deacetylase 9 [ Homo sapiens (human) ]

    Gene ID: 9734, updated on 17-Oct-2021

    Summary

    Official Symbol
    HDAC9provided by HGNC
    Official Full Name
    histone deacetylase 9provided by HGNC
    Primary source
    HGNC:HGNC:14065
    See related
    Ensembl:ENSG00000048052 MIM:606543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
    Summary
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.1), brain (RPKM 2.0) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See HDAC9 in Genome Data Viewer
    Location:
    7p21.1
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (18086825..19002416)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (18126448..19042039)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene MRM3 pseudogene 2 Neighboring gene phosphoribosyl pyrophosphate synthetase 1 like 1 Neighboring gene microRNA 1302-6 Neighboring gene GATA motif-containing MPRA enhancer 275 Neighboring gene uncharacterized LOC107986698 Neighboring gene casein kinase 1 alpha 1 pseudogene Neighboring gene eExon 18 TWIST1 limb enhancer Neighboring gene eExon 19 TWIST1 limb enhancer Neighboring gene VISTA enhancer hs644 Neighboring gene RN7SK pseudogene 266 Neighboring gene HDAC9 antisense RNA 1 Neighboring gene nucleophosmin 1 pseudogene 13 Neighboring gene twist family bHLH transcription factor 1 Neighboring gene Fer3 like bHLH transcription factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genetic predictors of medically refractory ulcerative colitis.
    GeneReviews: Not available
    Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.
    GeneReviews: Not available
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    GeneReviews: Not available
    Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.
    GeneReviews: Not available
    Genome-Wide Association Study of Intracranial Aneurysm Identifies a New Association on Chromosome 7.
    GeneReviews: Not available
    Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
    GeneReviews: Not available
    Genome-wide association study of retinopathy in individuals without diabetes.
    GeneReviews: Not available
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    GeneReviews: Not available
    Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
    GeneReviews: Not available
    Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0744, DKFZp779K1053

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA-binding transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase activity (H4-K16 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in B cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H4 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone H4-K16 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in histone deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in inflammatory response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of lipoprotein lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-lysine deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of skeletal muscle fiber development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of striated muscle cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of histone deacetylase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of histone methyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone deacetylase 9
    Names
    MEF-2 interacting transcription repressor (MITR) protein
    histone deacetylase 4/5-related protein
    histone deacetylase 7B
    NP_001191073.1
    NP_001191074.1
    NP_001191075.1
    NP_001191076.1
    NP_001191077.1
    NP_001308797.1
    NP_001308798.1
    NP_001308799.1
    NP_001308800.1
    NP_001308801.1
    NP_001308802.1
    NP_001308803.1
    NP_001308804.1
    NP_001308805.1
    NP_001308806.1
    NP_001308807.1
    NP_001308808.1
    NP_001308813.1
    NP_001308814.1
    NP_001308815.1
    NP_001308816.1
    NP_001308817.1
    NP_001308818.1
    NP_001308819.1
    NP_001308820.1
    NP_001308822.1
    NP_001308823.1
    NP_001308824.1
    NP_001308825.1
    NP_001308826.1
    NP_001308827.1
    NP_001308828.1
    NP_001308829.1
    NP_001308830.1
    NP_001308831.1
    NP_055522.1
    NP_478056.1
    NP_848510.1
    NP_848512.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023250.3 RefSeqGene

      Range
      413801..920468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204144.3NP_001191073.1  histone deacetylase 9 isoform 6

      See identical proteins and their annotated locations for NP_001191073.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) is longer at the N-terminus, has a shorter and distinct C-terminus, and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AC074193, AK304298, BC150328, DC333353
      Consensus CDS
      CCDS56465.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000401669.2, ENST00000417496.6
      Conserved Domains (1) summary
      cl25407
      Location:80166
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    2. NM_001204145.3NP_001191074.1  histone deacetylase 9 isoform 7

      See identical proteins and their annotated locations for NP_001191074.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an extended 5' UTR, differs in the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus and lacks an internal segment compared to isoform 1. Variants 7, 30 and 31 encode the same isoform (7).
      Source sequence(s)
      AC002433, AK297404, BC150328, DC333611
      Consensus CDS
      CCDS56466.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000395655.2, ENST00000428307.6
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    3. NM_001204146.2NP_001191075.1  histone deacetylase 9 isoform 8

      See identical proteins and their annotated locations for NP_001191075.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has an extended 5' UTR, differs in the 3' UTR and coding sequence, lacks an alternate in-frame exon, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (8) has a shorter and distinct C-terminus, lacks an internal segment, and contains an alternate short internal segment compared to isoform 1.
      Source sequence(s)
      AC002433, AK316109, BC150328, DC333611
      Consensus CDS
      CCDS75565.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Related
      ENSP00000478829.1, ENST00000622668.4
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    4. NM_001204147.3NP_001191076.1  histone deacetylase 9 isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (9) is shorter at the N-terminus, has a shorter and distinct C-terminus, and lacks an internal segment compared to isoform 1.
      Source sequence(s)
      AC002433, AK304343, AK304410, BC150328, DC369899
      Consensus CDS
      CCDS56468.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000430036.1, ENST00000524023.1
      Conserved Domains (1) summary
      cl25407
      Location:793
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    5. NM_001204148.3NP_001191077.1  histone deacetylase 9 isoform 10

      See identical proteins and their annotated locations for NP_001191077.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence, the 3' UTR and coding sequence, and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (10) is shorter at the N-terminus, has a shorter and distinct C-terminus, and contains an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AC002124, AC002433, AK304343, AK304410, BC150328, DC369899
      Consensus CDS
      CCDS56467.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000388568.2, ENST00000456174.6
      Conserved Domains (1) summary
      cd10163
      Location:796
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    6. NM_001321868.2NP_001308797.1  histone deacetylase 9 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC004744, AC074193, AJ459808, AK304298, BQ575888, DC333353
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (2) summary
      cd10163
      Location:60146
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:609986
      HDAC_classIIa; Histone deacetylases, class IIa
    7. NM_001321869.2NP_001308798.1  histone deacetylase 9 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Conserved Domains (1) summary
      cd10163
      Location:60149
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    8. NM_001321870.2NP_001308799.1  histone deacetylase 9 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Conserved Domains (1) summary
      cl25407
      Location:60146
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    9. NM_001321871.2NP_001308800.1  histone deacetylase 9 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC002433, AC074193, AK304298, BC150328, DC333353
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:60146
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    10. NM_001321872.2NP_001308801.1  histone deacetylase 9 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC074193, AJ459808, AK304298, AK316109, BC150328, DC333353
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Conserved Domains (1) summary
      cd10163
      Location:60149
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    11. NM_001321873.2NP_001308802.1  histone deacetylase 9 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC074193, AK304298, AK316109, BC150328, DC333353
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Conserved Domains (1) summary
      cd10163
      Location:60149
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    12. NM_001321874.2NP_001308803.1  histone deacetylase 9 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    13. NM_001321875.2NP_001308804.1  histone deacetylase 9 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    14. NM_001321876.2NP_001308805.1  histone deacetylase 9 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000505081.1, ENST00000681950.1
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    15. NM_001321877.2NP_001308806.1  histone deacetylase 9 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC002088, AC002124, AC002410, AC002433, AC004744, AC004994, BQ575888, DC333611
      Consensus CDS
      CCDS83163.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000383912.1, ENST00000401921.5
      Conserved Domains (2) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:590967
      HDAC_classIIa; Histone deacetylases, class IIa
    16. NM_001321878.2NP_001308807.1  histone deacetylase 9 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000506070.1, ENST00000681273.1
      Conserved Domains (1) summary
      cl23765
      Location:38124
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    17. NM_001321879.2NP_001308808.1  histone deacetylase 9 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    18. NM_001321884.2NP_001308813.1  histone deacetylase 9 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    19. NM_001321885.2NP_001308814.1  histone deacetylase 9 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    20. NM_001321886.2NP_001308815.1  histone deacetylase 9 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl23765
      Location:793
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    21. NM_001321887.2NP_001308816.1  histone deacetylase 9 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:796
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    22. NM_001321888.2NP_001308817.1  histone deacetylase 9 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    23. NM_001321889.2NP_001308818.1  histone deacetylase 9 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:796
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    24. NM_001321890.2NP_001308819.1  histone deacetylase 9 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    25. NM_001321891.2NP_001308820.1  histone deacetylase 9 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      Consensus CDS
      CCDS56466.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    26. NM_001321893.2NP_001308822.1  histone deacetylase 9 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328
      Consensus CDS
      CCDS56466.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    27. NM_001321894.2NP_001308823.1  histone deacetylase 9 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      Consensus CDS
      CCDS75565.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    28. NM_001321895.2NP_001308824.1  histone deacetylase 9 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      Consensus CDS
      CCDS75565.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      UniProtKB/TrEMBL
      B7Z3P7
      Related
      ENSP00000384017.1, ENST00000406072.5
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    29. NM_001321896.2NP_001308825.1  histone deacetylase 9 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, AC091697, BC150328
      Consensus CDS
      CCDS56467.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:796
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    30. NM_001321897.2NP_001308826.1  histone deacetylase 9 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC002088, AC002124, AC002410, AC002433, AC004744, AC004994, BQ575888, DC333611
      Consensus CDS
      CCDS83163.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (2) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:590967
      HDAC_classIIa; Histone deacetylases, class IIa
    31. NM_001321898.2NP_001308827.1  histone deacetylase 9 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    32. NM_001321899.2NP_001308828.1  histone deacetylase 9 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    33. NM_001321900.2NP_001308829.1  histone deacetylase 9 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      Consensus CDS
      CCDS47557.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    34. NM_001321901.2NP_001308830.1  histone deacetylase 9 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    35. NM_001321902.2NP_001308831.1  histone deacetylase 9 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC002124, AC002433, BC150328, DC333611
      UniProtKB/Swiss-Prot
      Q9UKV0
      Conserved Domains (1) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
    36. NM_014707.4NP_055522.1  histone deacetylase 9 isoform 3

      See identical proteins and their annotated locations for NP_055522.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks multiple 3' exons and has an alternate 3' segment including the coding region and UTR, compared to variant 1. The resulting isoform 3, also known as HDRP, has a much shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      BC152405
      Consensus CDS
      CCDS47557.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000384382.3, ENST00000405010.7
      Conserved Domains (1) summary
      cl25407
      Location:38124
      ClassIIa_HDAC_Gln-rich-N; Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9)
    37. NM_058176.2NP_478056.1  histone deacetylase 9 isoform 1

      See identical proteins and their annotated locations for NP_478056.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AA405905, AY032737, BC152405
      Consensus CDS
      CCDS47555.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000410337.2, ENST00000432645.6
      Conserved Domains (2) summary
      cd10163
      Location:38124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd10009
      Location:6311009
      HDAC9; Histone deacetylase 9
    38. NM_178423.3NP_848510.1  histone deacetylase 9 isoform 4

      See identical proteins and their annotated locations for NP_848510.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 3' sequence including the coding region and UTR, compared to variant 1. The resulting isoform 4, also known as HDAC9fl, has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC004744, AJ459808, BQ575888
      Consensus CDS
      CCDS47554.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000384657.3, ENST00000406451.8
      Conserved Domains (2) summary
      cd10163
      Location:38124
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:6311008
      HDAC_classIIa; Histone deacetylases, class IIa
    39. NM_178425.4NP_848512.1  histone deacetylase 9 isoform 5

      See identical proteins and their annotated locations for NP_848512.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 3' sequence including the coding region and UTR, compared to variant 1. The resulting isoform 5 has a distinct C-terminus, compared to isoform 1. This variant is incomplete at the 5' end.
      Source sequence(s)
      AC002088, AC002124, AC002410, AC002433, AC004744, AC004994
      Consensus CDS
      CCDS47553.1
      UniProtKB/Swiss-Prot
      Q9UKV0
      Related
      ENSP00000408617.2, ENST00000441542.7
      Conserved Domains (2) summary
      cd10163
      Location:38127
      ClassIIa_HDAC9_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC9, a Class IIa histone deacetylase
      cd11681
      Location:6341011
      HDAC_classIIa; Histone deacetylases, class IIa

    RNA

    1. NR_135835.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC002433, BC092441, DC333611

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

      Range
      18086825..19002416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_058177.2: Suppressed sequence

      Description
      NM_058177.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center