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    ZNF646 zinc finger protein 646 [ Homo sapiens (human) ]

    Gene ID: 9726, updated on 12-May-2019

    Summary

    Official Symbol
    ZNF646provided by HGNC
    Official Full Name
    zinc finger protein 646provided by HGNC
    Primary source
    HGNC:HGNC:29004
    See related
    Ensembl:ENSG00000167395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 13.8), spleen (RPKM 4.2) and 23 other tissues See more
    Orthologs

    Genomic context

    See ZNF646 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (31073665..31083512)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31085581..31094833)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928762 Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex subunit 1 Neighboring gene branched chain keto acid dehydrogenase kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0296

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014699.3NP_055514.3  zinc finger protein 646

      See identical proteins and their annotated locations for NP_055514.3

      Status: VALIDATED

      Source sequence(s)
      AC135050, BC035589
      Consensus CDS
      CCDS10702.1
      UniProtKB/Swiss-Prot
      O15015
      Related
      ENSP00000300850.5, ENST00000300850.5
      Conserved Domains (3) summary
      COG5048
      Location:222419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:12321252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:17181743
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

      Range
      31073665..31083512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005255710.4XP_005255767.1  zinc finger protein 646 isoform X1

      See identical proteins and their annotated locations for XP_005255767.1

      UniProtKB/Swiss-Prot
      O15015
      Conserved Domains (3) summary
      COG5048
      Location:222419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:12321252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:17181743
      zf-H2C2_2; Zinc-finger double domain
    2. XM_005255711.4XP_005255768.1  zinc finger protein 646 isoform X1

      See identical proteins and their annotated locations for XP_005255768.1

      UniProtKB/Swiss-Prot
      O15015
      Conserved Domains (3) summary
      COG5048
      Location:222419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:12321252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:17181743
      zf-H2C2_2; Zinc-finger double domain
    3. XM_005255712.4XP_005255769.1  zinc finger protein 646 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:222419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:12321252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:17181743
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011545990.2XP_011544292.1  zinc finger protein 646 isoform X1

      See identical proteins and their annotated locations for XP_011544292.1

      UniProtKB/Swiss-Prot
      O15015
      Conserved Domains (3) summary
      COG5048
      Location:222419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:12321252
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:17181743
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_001752041.1 RNA Sequence

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