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    VGLL4 vestigial like family member 4 [ Homo sapiens (human) ]

    Gene ID: 9686, updated on 17-Jun-2019

    Summary

    Official Symbol
    VGLL4provided by HGNC
    Official Full Name
    vestigial like family member 4provided by HGNC
    Primary source
    HGNC:HGNC:28966
    See related
    Ensembl:ENSG00000144560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VGL-4
    Expression
    Ubiquitous expression in ovary (RPKM 26.1), thyroid (RPKM 18.5) and 25 other tissues See more
    Orthologs

    Genomic context

    See VGLL4 in Genome Data Viewer
    Location:
    3p25.3-p25.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (11556067..11720715, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11597543..11762220, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene histamine receptor H1 Neighboring gene Sharpr-MPRA regulatory region 13806 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene autophagy related 7 Neighboring gene uncharacterized LOC105376952 Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog Neighboring gene FANCD2 pseudogene 2 Neighboring gene CYCS pseudogene 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa.
    NHGRI GWA Catalog
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    NHGRI GWA Catalog
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    NHGRI GWA Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0121

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    transcription cofactor vestigial-like protein 4
    Names
    Vestigial-like 4
    vestigial like 4

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128219.3NP_001121691.1  transcription cofactor vestigial-like protein 4 isoform a

      See identical proteins and their annotated locations for NP_001121691.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BU682809, D50911, DA383197, DA386938, DR159250
      Consensus CDS
      CCDS46754.1
      UniProtKB/Swiss-Prot
      Q14135
      UniProtKB/TrEMBL
      G5E9M7
      Related
      ENSP00000404251.2, ENST00000430365.7
      Conserved Domains (2) summary
      smart00711
      Location:240255
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:14230
      VGLL4; Transcription cofactor vestigial-like protein 4
    2. NM_001128220.3NP_001121692.1  transcription cofactor vestigial-like protein 4 isoform c

      See identical proteins and their annotated locations for NP_001121692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK307708, BU682809, D50911
      Consensus CDS
      CCDS46755.1
      UniProtKB/Swiss-Prot
      Q14135
      Related
      ENSP00000416615.2, ENST00000451674.6
      Conserved Domains (2) summary
      smart00711
      Location:154169
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:6144
      VGLL4; Transcription cofactor vestigial-like protein 4
    3. NM_001128221.3NP_001121693.1  transcription cofactor vestigial-like protein 4 isoform d

      See identical proteins and their annotated locations for NP_001121693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK308761, BU682809, D50911
      Consensus CDS
      CCDS46756.1
      UniProtKB/Swiss-Prot
      Q14135
      Related
      ENSP00000402878.2, ENST00000424529.6
      Conserved Domains (2) summary
      smart00711
      Location:150165
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:1140
      VGLL4; Transcription cofactor vestigial-like protein 4
    4. NM_001284390.2NP_001271319.1  transcription cofactor vestigial-like protein 4 isoform e

      See identical proteins and their annotated locations for NP_001271319.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      BC000763, BU682809, D50911, DA383197
      Consensus CDS
      CCDS68343.1
      UniProtKB/Swiss-Prot
      Q14135
      UniProtKB/TrEMBL
      A0A0A6YYI5
      Related
      ENSP00000413030.2, ENST00000426568.5
      Conserved Domains (2) summary
      smart00711
      Location:239254
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:27229
      VGLL4; Transcription cofactor vestigial-like protein 4
    5. NM_001284391.1NP_001271320.1  transcription cofactor vestigial-like protein 4 isoform f

      See identical proteins and their annotated locations for NP_001271320.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (f) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC022001, AI809612, AK300344, BU682809, D50911, DA383197
      Consensus CDS
      CCDS68342.1
      UniProtKB/Swiss-Prot
      Q14135
      UniProtKB/TrEMBL
      G5E9M9
      Related
      ENSP00000404624.1, ENST00000413604.5
      Conserved Domains (2) summary
      smart00711
      Location:175190
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:1165
      VGLL4; Transcription cofactor vestigial-like protein 4
    6. NM_014667.4NP_055482.2  transcription cofactor vestigial-like protein 4 isoform b

      See identical proteins and their annotated locations for NP_055482.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK130542, BU682809, D50911, DA383197
      Consensus CDS
      CCDS2606.1
      UniProtKB/Swiss-Prot
      Q14135
      UniProtKB/TrEMBL
      A0A075B6E4
      Related
      ENSP00000273038.3, ENST00000273038.7
      Conserved Domains (2) summary
      smart00711
      Location:234249
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8223
      VGLL4; Transcription cofactor vestigial-like protein 4

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      11556067..11720715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007542.1XP_016863031.1  transcription cofactor vestigial-like protein 4 isoform X5

      Related
      ENSP00000412923.1, ENST00000445411.5
      Conserved Domains (1) summary
      pfam15245
      Location:8204
      VGLL4; Transcription cofactor vestigial-like protein 4
    2. XM_024453835.1XP_024309603.1  transcription cofactor vestigial-like protein 4 isoform X3

      Conserved Domains (2) summary
      smart00711
      Location:234249
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8223
      VGLL4; Transcription cofactor vestigial-like protein 4
    3. XM_024453837.1XP_024309605.1  transcription cofactor vestigial-like protein 4 isoform X5

      Related
      ENSP00000394439.1, ENST00000418000.5
      Conserved Domains (1) summary
      pfam15245
      Location:8204
      VGLL4; Transcription cofactor vestigial-like protein 4
    4. XM_017007541.1XP_016863030.1  transcription cofactor vestigial-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0A6YYI5
      Conserved Domains (2) summary
      smart00711
      Location:239254
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:27229
      VGLL4; Transcription cofactor vestigial-like protein 4
    5. XM_011534267.2XP_011532569.1  transcription cofactor vestigial-like protein 4 isoform X2

      Conserved Domains (2) summary
      smart00711
      Location:235250
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:23225
      VGLL4; Transcription cofactor vestigial-like protein 4
    6. XM_024453836.1XP_024309604.1  transcription cofactor vestigial-like protein 4 isoform X3

      Conserved Domains (2) summary
      smart00711
      Location:234249
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8223
      VGLL4; Transcription cofactor vestigial-like protein 4
    7. XM_011534269.1XP_011532571.1  transcription cofactor vestigial-like protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011532571.1

      UniProtKB/TrEMBL
      G5E9M9
      Conserved Domains (2) summary
      smart00711
      Location:175190
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:1165
      VGLL4; Transcription cofactor vestigial-like protein 4
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