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    FEZ2 fasciculation and elongation protein zeta 2 [ Homo sapiens (human) ]

    Gene ID: 9637, updated on 11-Jun-2021

    Summary

    Official Symbol
    FEZ2provided by HGNC
    Official Full Name
    fasciculation and elongation protein zeta 2provided by HGNC
    Primary source
    HGNC:HGNC:3660
    See related
    Ensembl:ENSG00000171055 MIM:604826
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HUM3CL
    Summary
    This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 32.7), brain (RPKM 29.1) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FEZ2 in Genome Data Viewer
    Location:
    2p22.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (36552239..36598190, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (36779401..36825311, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRIM1 divergent transcript Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene Sharpr-MPRA regulatory region 2322 Neighboring gene RACK1 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117372

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    fasciculation and elongation protein zeta-2
    Names
    pre-T/NK cell associated protein (3Cl)
    zygin 2
    zygin II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042548.2NP_001036013.1  fasciculation and elongation protein zeta-2 isoform 2

      See identical proteins and their annotated locations for NP_001036013.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1, resulting in a longer protein isoform.
      Source sequence(s)
      AC007401, BC089390
      Consensus CDS
      CCDS46258.1
      UniProtKB/Swiss-Prot
      Q9UHY8
      Related
      ENSP00000368547.4, ENST00000379245.8
      Conserved Domains (1) summary
      pfam07763
      Location:51270
      FEZ; FEZ-like protein
    2. NM_005102.3NP_005093.2  fasciculation and elongation protein zeta-2 isoform 1

      See identical proteins and their annotated locations for NP_005093.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the more abundant transcript.
      Source sequence(s)
      AC007401, BC037566
      Consensus CDS
      CCDS46257.1
      UniProtKB/Swiss-Prot
      Q9UHY8
      Related
      ENSP00000385112.3, ENST00000405912.8
      Conserved Domains (1) summary
      pfam07763
      Location:51270
      FEZ; FEZ-like protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      36552239..36598190 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712153.2XP_006712216.1  fasciculation and elongation protein zeta-2 isoform X1

      Related
      ENSP00000350685.4, ENST00000357996.4
      Conserved Domains (1) summary
      pfam07763
      Location:1169
      FEZ; FEZ-like protein

    RNA

    1. XR_244972.3 RNA Sequence

      Related
      ENST00000451623.5
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