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    PSMF1 proteasome inhibitor subunit 1 [ Homo sapiens (human) ]

    Gene ID: 9491, updated on 8-Aug-2021

    Summary

    Official Symbol
    PSMF1provided by HGNC
    Official Full Name
    proteasome inhibitor subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:9571
    See related
    Ensembl:ENSG00000125818 MIM:617858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PI31
    Summary
    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 17.3), ovary (RPKM 9.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PSMF1 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (1113263..1172246)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (1093906..1152890)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1111 Neighboring gene uncharacterized LOC105372494 Neighboring gene uncharacterized LOC105372493 Neighboring gene Sharpr-MPRA regulatory region 3766 Neighboring gene actin gamma 1 pseudogene 3 Neighboring gene uncharacterized LOC105372496 Neighboring gene transmembrane protein 74B Neighboring gene chromosome 20 open reading frame 202

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
    tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
    tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
    tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
    Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
    integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    proteasome inhibitor PI31 subunit
    Names
    proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323407.2NP_001310336.1  proteasome inhibitor PI31 subunit isoform 3

      Status: REVIEWED

      Source sequence(s)
      AA699495, AK302164, AL031665, BC126462
      UniProtKB/Swiss-Prot
      Q92530
      UniProtKB/TrEMBL
      B4DXW9
    2. NM_001323408.2NP_001310337.1  proteasome inhibitor PI31 subunit isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA699495, AL031665, DC398668
      Consensus CDS
      CCDS82589.1
      UniProtKB/TrEMBL
      Q5QPM7
      Related
      ENSP00000246015.4, ENST00000246015.8
      Conserved Domains (2) summary
      pfam08577
      Location:182248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11148
      PI31_Prot_N; PI31 proteasome regulator N-terminal
    3. NM_001323409.2NP_001310338.1  proteasome inhibitor PI31 subunit isoform 5

      Status: REVIEWED

      Source sequence(s)
      AA699495, AL031665, DC398668
      Conserved Domains (2) summary
      pfam08577
      Location:182248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11148
      PI31_Prot_N; PI31 proteasome regulator N-terminal
    4. NM_001323410.2NP_001310339.1  proteasome inhibitor PI31 subunit isoform 6

      Status: REVIEWED

      Source sequence(s)
      AA699495, AL031665, DC398668
      Conserved Domains (2) summary
      pfam08577
      Location:182248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11148
      PI31_Prot_N; PI31 proteasome regulator N-terminal
    5. NM_006814.5NP_006805.2  proteasome inhibitor PI31 subunit isoform 1

      See identical proteins and their annotated locations for NP_006805.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA699495, AL031665, BC126127, D88378, DC398668
      Consensus CDS
      CCDS13010.1
      UniProtKB/Swiss-Prot
      Q92530
      UniProtKB/TrEMBL
      A0A140VJT2
      Related
      ENSP00000338039.6, ENST00000335877.11
      Conserved Domains (2) summary
      pfam08577
      Location:182248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11148
      PI31_Prot_N; PI31 proteasome regulator N-terminal
    6. NM_178578.4NP_848693.2  proteasome inhibitor PI31 subunit isoform 1

      See identical proteins and their annotated locations for NP_848693.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA699495, AF055032, AL031665, BC126462, DA949012, DC398121
      Consensus CDS
      CCDS13010.1
      UniProtKB/Swiss-Prot
      Q92530
      UniProtKB/TrEMBL
      A0A140VJT2
      Related
      ENSP00000327704.3, ENST00000333082.7
      Conserved Domains (2) summary
      pfam08577
      Location:182248
      PI31_Prot_C; PI31 proteasome regulator
      pfam11566
      Location:11148
      PI31_Prot_N; PI31 proteasome regulator N-terminal

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

      Range
      1113263..1172246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178579.1: Suppressed sequence

      Description
      NM_178579.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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