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    FOXQ1 forkhead box Q1 [ Homo sapiens (human) ]

    Gene ID: 94234, updated on 17-Jun-2019

    Summary

    Official Symbol
    FOXQ1provided by HGNC
    Official Full Name
    forkhead box Q1provided by HGNC
    Primary source
    HGNC:HGNC:20951
    See related
    Ensembl:ENSG00000164379 MIM:612788
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HFH1
    Summary
    FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM, May 2009]
    Orthologs

    Genomic context

    See FOXQ1 in Genome Data Viewer
    Location:
    6p25.3
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (1312098..1314758)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (1312675..1314993)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1622 Neighboring gene uncharacterized LOC105374879 Neighboring gene uncharacterized LOC107986554 Neighboring gene uncharacterized LOC112267978 Neighboring gene long intergenic non-protein coding RNA 1394 Neighboring gene uncharacterized LOC105374880

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of pancreatic cancer in Japanese population.
    NHGRI GWA Catalog
    Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
    NHGRI GWA Catalog
    Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
    NHGRI GWA Catalog

    Pathways from BioSystems

    • Preimplantation Embryo, organism-specific biosystem (from WikiPathways)
      Preimplantation Embryo, organism-specific biosystemThe source of this pathway is RNA-Seq data from single-cell pre-implantation embryos (Supplemental Table 1): http://www.nature.com/nsmb/journal/v20/n9/full/nsmb.2660.html Analysis options for runnin...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    hair follicle morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    forkhead box protein Q1
    Names
    HFH-1
    HNF-3/forkhead-like protein 1
    hepatocyte nuclear factor 3 forkhead homolog 1
    winged helix/forkhead transcription factor

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033260.4NP_150285.3  forkhead box protein Q1

      See identical proteins and their annotated locations for NP_150285.3

      Status: VALIDATED

      Source sequence(s)
      AL499606, BC053850, BU566731
      Consensus CDS
      CCDS4471.1
      UniProtKB/Swiss-Prot
      Q9C009
      Related
      ENSP00000296839.2, ENST00000296839.5
      Conserved Domains (1) summary
      cd00059
      Location:119197
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      1312098..1314758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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