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    NTN1 netrin 1 [ Homo sapiens (human) ]

    Gene ID: 9423, updated on 15-Jun-2019

    Summary

    Official Symbol
    NTN1provided by HGNC
    Official Full Name
    netrin 1provided by HGNC
    Primary source
    HGNC:HGNC:8029
    See related
    Ensembl:ENSG00000065320 MIM:601614
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRMV4; NTN1L
    Summary
    Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in heart (RPKM 20.8), esophagus (RPKM 16.8) and 17 other tissues See more
    Orthologs

    Genomic context

    See NTN1 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (9021542..9244000)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8924859..9147317)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985063 Neighboring gene phosphoinositide-3-kinase regulatory subunit 5 Neighboring gene uncharacterized CTB-41I6.1 Neighboring gene uncharacterized LOC101928266 Neighboring gene uncharacterized LOC105371532 Neighboring gene uncharacterized LOC105371531 Neighboring gene syntaxin 8 Neighboring gene ribosomal protein L19 pseudogene 18 Neighboring gene cilia and flagella associated protein 52

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    MIRROR MOVEMENTS 4
    MedGen: CN258051 OMIM: 618264 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.
    NHGRI GWA Catalog
    Identification of inherited genetic variations influencing prognosis in early-onset breast cancer.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of netrin 1 (NTN1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell-Cell communication, organism-specific biosystem (from REACTOME)
      Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
    • DCC mediated attractive signaling, organism-specific biosystem (from REACTOME)
      DCC mediated attractive signaling, organism-specific biosystemThe DCC family includes DCC and neogenin in vertebrates. DCC is required for netrin-induced axon attraction. DCC is a transmembrane protein lacking any identifiable catalytic activity. Protein tyrosi...
    • DSCAM interactions, organism-specific biosystem (from REACTOME)
      DSCAM interactions, organism-specific biosystemDSCAM (Down syndrome cell adhesion molecule) is one of the members of the Ig superfamily CAMs with a domain architecture comprising 10 Ig domains, 6 fibronectin type III (FN) repeats, a single transm...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Netrin mediated repulsion signals, organism-specific biosystem (from REACTOME)
      Netrin mediated repulsion signals, organism-specific biosystemUnc5 netrin receptors mediate repellent responses to netrin. Four Unc5 members have been found in humans: Unc5A, B, C and D. Different studies have suggested that long-range repulsion to netrin requi...
    • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...
    • Role of second messengers in netrin-1 signaling, organism-specific biosystem (from REACTOME)
      Role of second messengers in netrin-1 signaling, organism-specific biosystemThe levels of second messengers such as Ca+2, cAMP and cGMP may regulate the response of the growth cone to a particular cue. Netrin-1 as a guidance molecule depends on intracellular Ca+2 concentrati...
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Cdc42 protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    anterior/posterior axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    chemorepulsion of axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inner ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    motor neuron axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of netrin-activated signaling pathway TAS
    Traceable Author Statement
    more info
     
    neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of axon extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell motility ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    substrate-dependent cell migration, cell extension ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    netrin-1
    Names
    epididymis tissue protein Li 131P
    netrin 1, mouse, homolog of

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004822.3NP_004813.2  netrin-1 precursor

      See identical proteins and their annotated locations for NP_004813.2

      Status: REVIEWED

      Source sequence(s)
      AC005695, AC090610, U75586
      Consensus CDS
      CCDS11148.1
      UniProtKB/Swiss-Prot
      O95631
      Related
      ENSP00000173229.2, ENST00000173229.7
      Conserved Domains (4) summary
      smart00136
      Location:46283
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:284329
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:487601
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      pfam00053
      Location:404441
      Laminin_EGF; Laminin EGF domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      Range
      9021510..9244000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006721595.3XP_006721658.1  netrin-1 isoform X1

      See identical proteins and their annotated locations for XP_006721658.1

      UniProtKB/Swiss-Prot
      O95631
      Conserved Domains (4) summary
      smart00136
      Location:46283
      LamNT; Laminin N-terminal domain (domain VI)
      cd00055
      Location:284329
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd03579
      Location:487601
      NTR_netrin-1_like; NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration ...
      pfam00053
      Location:404441
      Laminin_EGF; Laminin EGF domain
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