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    CNOT8 CCR4-NOT transcription complex subunit 8 [ Homo sapiens (human) ]

    Gene ID: 9337, updated on 9-Aug-2021

    Summary

    Official Symbol
    CNOT8provided by HGNC
    Official Full Name
    CCR4-NOT transcription complex subunit 8provided by HGNC
    Primary source
    HGNC:HGNC:9207
    See related
    Ensembl:ENSG00000155508 MIM:603731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAF1; POP2; CALIF; Caf1b; hCAF1
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.1), lymph node (RPKM 19.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See CNOT8 in Genome Data Viewer
    Location:
    5q33.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (154857952..154876792)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (154237809..154256352)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene La ribonucleoprotein 1, translational regulator Neighboring gene uncharacterized LOC112267936 Neighboring gene fatty acid hydroxylase domain containing 2 Neighboring gene microRNA 378h Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene mitochondrial ribosomal protein L22

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-5'-exoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A)-specific ribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables poly(A)-specific ribonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 8
    Names
    CAF1-like protein
    CAF2
    CALIFp
    CCR4-associated factor 8
    PGK promoter directed over production
    NP_001288002.1
    NP_001288003.1
    NP_001288004.1
    NP_001288006.1
    NP_001288009.1
    NP_001288011.1
    NP_001288012.1
    NP_001288015.1
    NP_004770.4
    XP_005268584.1
    XP_011536008.1
    XP_011536010.1
    XP_016865537.1
    XP_016865538.1
    XP_016865539.1
    XP_016865540.1
    XP_016865541.1
    XP_016865542.1
    XP_016865543.1
    XP_016865544.1
    XP_016865545.1
    XP_016865546.1
    XP_016865547.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301073.2NP_001288002.1  CCR4-NOT transcription complex subunit 8 isoform 1

      See identical proteins and their annotated locations for NP_001288002.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and encode the same isoform (1), compared to variant 1.
      Source sequence(s)
      AK025358, AL122045
      Consensus CDS
      CCDS4329.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000285896.6, ENST00000285896.11
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    2. NM_001301074.2NP_001288003.1  CCR4-NOT transcription complex subunit 8 isoform 2

      See identical proteins and their annotated locations for NP_001288003.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK303775, AK314317, AL122045
      Consensus CDS
      CCDS75361.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000430833.1, ENST00000519404.5
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    3. NM_001301075.2NP_001288004.1  CCR4-NOT transcription complex subunit 8 isoform 3

      See identical proteins and their annotated locations for NP_001288004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
      Source sequence(s)
      AK297381, AK314317, AL122045
      Consensus CDS
      CCDS78074.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    4. NM_001301077.2NP_001288006.1  CCR4-NOT transcription complex subunit 8 isoform 3

      See identical proteins and their annotated locations for NP_001288006.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
      Source sequence(s)
      AK309359, AL122045, DC387160
      Consensus CDS
      CCDS78074.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000429882.1, ENST00000521583.5
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    5. NM_001301080.2NP_001288009.1  CCR4-NOT transcription complex subunit 8 isoform 3

      See identical proteins and their annotated locations for NP_001288009.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an alternate splice site and lacks two internal exons in the 5' region, which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
      Source sequence(s)
      AK315864, AL122045
      Consensus CDS
      CCDS78074.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000428305.1, ENST00000520671.5
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    6. NM_001301082.1NP_001288011.1  CCR4-NOT transcription complex subunit 8 isoform 3

      See identical proteins and their annotated locations for NP_001288011.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) has multiple differences in the 5' region, one of which results in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
      Source sequence(s)
      AK316221, AL122045
      Consensus CDS
      CCDS78074.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000431034.1, ENST00000521450.5
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    7. NM_001301083.1NP_001288012.1  CCR4-NOT transcription complex subunit 8 isoform 3

      See identical proteins and their annotated locations for NP_001288012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) has an alternate 5' UTR exon and also lacks two consecutive internal exons, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 4, 5, 6, 7 and 8 encode the same isoform 3.
      Source sequence(s)
      AK316269, AL122045, AL520837
      Consensus CDS
      CCDS78074.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000428565.1, ENST00000523698.5
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    8. NM_001301086.2NP_001288015.1  CCR4-NOT transcription complex subunit 8 isoform 4

      See identical proteins and their annotated locations for NP_001288015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) has an alternate splice site and lacks two internal exons in the 5' region, which result in translation initiation at a downstream in-frame AUG, compared to variant 1. The resulting isoform (4) has a shorter N-terminus, compared to variant 1.
      Source sequence(s)
      AK315864, AK316055, AL122045
      Consensus CDS
      CCDS78075.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      UniProtKB/TrEMBL
      B7Z9U0
      Related
      ENSP00000429576.1, ENST00000524105.5
      Conserved Domains (1) summary
      cl23804
      Location:199
      CAF1; CAF1 family ribonuclease
    9. NM_004779.6NP_004770.4  CCR4-NOT transcription complex subunit 8 isoform 1

      See identical proteins and their annotated locations for NP_004770.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AK314317, AL122045
      Consensus CDS
      CCDS4329.1
      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000384747.2, ENST00000403027.6
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

      Range
      154857952..154876792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010051.1XP_016865540.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    2. XM_017010053.1XP_016865542.1  CCR4-NOT transcription complex subunit 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    3. XM_005268527.2XP_005268584.1  CCR4-NOT transcription complex subunit 8 isoform X2

      See identical proteins and their annotated locations for XP_005268584.1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    4. XM_017010050.1XP_016865539.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    5. XM_017010052.1XP_016865541.1  CCR4-NOT transcription complex subunit 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    6. XM_017010049.2XP_016865538.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    7. XM_011537708.2XP_011536010.1  CCR4-NOT transcription complex subunit 8 isoform X3

      See identical proteins and their annotated locations for XP_011536010.1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    8. XM_017010048.2XP_016865537.1  CCR4-NOT transcription complex subunit 8 isoform X1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000430493.1, ENST00000517876.5
      Conserved Domains (1) summary
      cl23804
      Location:1263
      CAF1; CAF1 family ribonuclease
    9. XM_017010057.1XP_016865546.1  CCR4-NOT transcription complex subunit 8 isoform X3

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
    10. XM_017010055.2XP_016865544.1  CCR4-NOT transcription complex subunit 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9UFF9
      Related
      ENSP00000429394.1, ENST00000518775.5
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    11. XM_017010054.2XP_016865543.1  CCR4-NOT transcription complex subunit 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    12. XM_017010058.2XP_016865547.1  CCR4-NOT transcription complex subunit 8 isoform X4

      UniProtKB/TrEMBL
      B7Z9U0
      Conserved Domains (1) summary
      cl23804
      Location:199
      CAF1; CAF1 family ribonuclease
    13. XM_017010056.1XP_016865545.1  CCR4-NOT transcription complex subunit 8 isoform X2

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1209
      CAF1; CAF1 family ribonuclease
    14. XM_011537706.1XP_011536008.1  CCR4-NOT transcription complex subunit 8 isoform X3

      See identical proteins and their annotated locations for XP_011536008.1

      UniProtKB/Swiss-Prot
      Q9UFF9
      Conserved Domains (1) summary
      cl23804
      Location:1157
      CAF1; CAF1 family ribonuclease
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