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    CD22 CD22 molecule [ Homo sapiens (human) ]

    Gene ID: 933, updated on 17-Jun-2019

    Summary

    Official Symbol
    CD22provided by HGNC
    Official Full Name
    CD22 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1643
    See related
    Ensembl:ENSG00000012124 MIM:107266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIGLEC2; SIGLEC-2
    Expression
    Biased expression in lymph node (RPKM 101.0), ovary (RPKM 64.7) and 2 other tissues See more
    Orthologs

    Genomic context

    See CD22 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35329169..35347361)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35820069..35838264)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene hepcidin antimicrobial peptide Neighboring gene myelin associated glycoprotein Neighboring gene microRNA 5196 Neighboring gene free fatty acid receptor 1 Neighboring gene free fatty acid receptor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef B lymphocytes exposed to supernatants from HIV-1 Nef-expressing macrophages have upregulated expression of receptors CD22, CD54, and CD58 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
      Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe functional B-cell receptor is a multi-protein complex consisting of an antigen binding subunit and a signaling subunit. The antigen binding subunit is the membrane bound immunoglobulin and the si...
    • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • B cell receptor signaling pathway, conserved biosystem (from KEGG)
      B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • CD22 mediated BCR regulation, organism-specific biosystem (from REACTOME)
      CD22 mediated BCR regulation, organism-specific biosystemBCR activation is highly regulated and coreceptors like CD22 (SIGLEC2) set a signalling threshold to prevent aberrant immune response and autoimmune disease (Cyster et al. 1997, Han et al. 2005). CD2...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: MAG

    Homology

    Clone Names

    • FLJ22814, MGC130020

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    CD4 receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    IgM binding TAS
    Traceable Author Statement
    more info
    PubMed 
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein phosphatase binding TAS
    Traceable Author Statement
    more info
    PubMed 
    sialic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    sialic acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of B cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of B cell receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of immunoglobulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    integral component of membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    B-cell receptor CD22
    Names
    B-lymphocyte cell adhesion molecule
    BL-CAM
    CD22 antigen
    T-cell surface antigen Leu-14
    sialic acid-binding Ig-like lectin 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185099.2NP_001172028.1  B-cell receptor CD22 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK225625, AK225694, X59350
      Consensus CDS
      CCDS54248.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000442279.1, ENST00000536635.6
      Conserved Domains (5) summary
      smart00408
      Location:257316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:518589
      IG_like; Immunoglobulin like
      pfam07679
      Location:242327
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain
    2. NM_001185100.2NP_001172029.1  B-cell receptor CD22 isoform 3 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC109306, BC109307, DA989528, DB333800, U62631, X59350
      Consensus CDS
      CCDS54247.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000441237.1, ENST00000544992.6
      Conserved Domains (6) summary
      smart00408
      Location:257316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:606677
      IG_like; Immunoglobulin like
      pfam07679
      Location:242327
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:335400
      Ig_3; Immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain
    3. NM_001185101.1NP_001172030.1  B-cell receptor CD22 isoform 4 precursor

      See identical proteins and their annotated locations for NP_001172030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC109306, DA989528, DB333800, X52785, X59350
      Consensus CDS
      CCDS54249.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000339349.6, ENST00000341773.10
      Conserved Domains (5) summary
      smart00408
      Location:431489
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:429500
      IG_like; Immunoglobulin like
      pfam07679
      Location:333412
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain
    4. NM_001278417.2NP_001265346.1  B-cell receptor CD22 isoform 5

      See identical proteins and their annotated locations for NP_001265346.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks the exon containing the translation initiation site and uses an alternate splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BC109306, BQ054599, CF138699, KC877723, U62631
      Consensus CDS
      CCDS62634.1
      UniProtKB/Swiss-Prot
      P20273
      Related
      ENSP00000403822.2, ENST00000419549.6
      Conserved Domains (4) summary
      smart00410
      Location:434505
      IG_like; Immunoglobulin like
      pfam13927
      Location:163228
      Ig_3; Immunoglobulin domain
      cl11960
      Location:456
      Ig; Immunoglobulin domain
      cl28434
      Location:70155
      I-set; Immunoglobulin I-set domain
    5. NM_001771.4NP_001762.2  B-cell receptor CD22 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001762.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK225625, AK225694, BC109306, DB333800, X59350
      Consensus CDS
      CCDS12457.1
      UniProtKB/Swiss-Prot
      P20273
      UniProtKB/TrEMBL
      Q0EAF5
      Related
      ENSP00000085219.4, ENST00000085219.10
      Conserved Domains (6) summary
      smart00408
      Location:257316
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:606677
      IG_like; Immunoglobulin like
      pfam07679
      Location:242327
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:143228
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13927
      Location:335400
      Ig_3; Immunoglobulin domain
      cl11960
      Location:24122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      35329169..35347361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024916.1: Suppressed sequence

      Description
      NM_024916.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.
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