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    TRIP4 thyroid hormone receptor interactor 4 [ Homo sapiens (human) ]

    Gene ID: 9325, updated on 16-Apr-2024

    Summary

    Official Symbol
    TRIP4provided by HGNC
    Official Full Name
    thyroid hormone receptor interactor 4provided by HGNC
    Primary source
    HGNC:HGNC:12310
    See related
    Ensembl:ENSG00000103671 MIM:604501; AllianceGenome:HGNC:12310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASC1; ASC-1; MDCDC; SMABF1; ZC2HC5; HsT17391
    Summary
    This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1). [provided by RefSeq, Apr 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 15.4), kidney (RPKM 11.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    15q22.31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (64387836..64455303)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62197257..62264725)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64680035..64747502)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene casein kinase 1 gamma 1 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6533 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64652953-64653179 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64673301-64673811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64679750-64680250 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64680251-64680751 Neighboring gene PCNA clamp associated factor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722213-64722724 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:64722725-64723236 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:64736443-64737642 Neighboring gene uncharacterized LOC105370861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6535 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9569 Neighboring gene zinc finger protein 609 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:64803884-64804071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64820886-64821752 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64831500-64832000 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:64832001-64832501 Neighboring gene uncharacterized LOC101930091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9571 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 61 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64849587-64850088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:64850089-64850588 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855291-64855860 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:64855861-64856430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9572 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9573 Neighboring gene ribosomal protein S26 pseudogene 50

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear estrogen receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of activating signal cointegrator 1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    activating signal cointegrator 1
    Names
    TR-interacting protein 4
    TRIP-4
    thyroid receptor-interacting protein 4
    zinc finger, C2HC5-type

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046848.1 RefSeqGene

      Range
      5033..72500
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321924.2NP_001308853.1  activating signal cointegrator 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate donor splice site at the 5' terminal exon, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK314319, BC012448, DA712387
      UniProtKB/Swiss-Prot
      Q15650
      Conserved Domains (1) summary
      cd06554
      Location:204317
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
    2. NM_016213.5NP_057297.2  activating signal cointegrator 1 isoform 1

      See identical proteins and their annotated locations for NP_057297.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK314319, BC012448, BG166305
      Consensus CDS
      CCDS10194.1
      UniProtKB/Swiss-Prot
      B2RAS0, Q15650, Q96ED7, Q9UKH0
      Related
      ENSP00000261884.3, ENST00000261884.8
      Conserved Domains (2) summary
      cd06554
      Location:434547
      ASCH_ASC-1_like; ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain ...
      pfam06221
      Location:168216
      zf-C2HC5; Putative zinc finger motif, C2HC5-type

    RNA

    1. NR_135855.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal exon compared to variant 1. It is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK314319, BC012448, BG166305

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      64387836..64455303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      62197257..62264725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)