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    DMKN dermokine [ Homo sapiens (human) ]

    Gene ID: 93099, updated on 17-Jun-2019

    Summary

    Official Symbol
    DMKNprovided by HGNC
    Official Full Name
    dermokineprovided by HGNC
    Primary source
    HGNC:HGNC:25063
    See related
    Ensembl:ENSG00000161249 MIM:617211
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ729; ZD52F10
    Summary
    This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
    Expression
    Biased expression in skin (RPKM 387.3) and esophagus (RPKM 47.0) See more
    Orthologs

    Genomic context

    See DMKN in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (35497217..35513678, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35988119..36004560, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene free fatty acid receptor 2 Neighboring gene keratinocyte differentiation associated protein Neighboring gene suprabasin Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene TMEM147 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ79374

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cornified envelope assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    dermokine
    Names
    epidermis-specific secreted protein SK30/SK89

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035516.4NP_001030593.2  dermokine isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (1, also referred to as isoform alpha) has a distinct N-terminus and is shorter than isoform 2.
      Source sequence(s)
      AD001502
      Consensus CDS
      CCDS42549.1
      Related
      ENSP00000386225.2, ENST00000408915.6
    2. NM_001126056.3NP_001119528.3  dermokine isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and contains three additional alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 3, also referred to as isoform beta-2), compared to isoform 2.
      Source sequence(s)
      AC138125, AD001502
      Consensus CDS
      CCDS46054.2
      Related
      ENSP00000391036.1, ENST00000419602.5
    3. NM_001126057.3NP_001119529.2  dermokine isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (5, also referred to as isoform gamma 2) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AC138125, AY358412, AY789697
      Consensus CDS
      CCDS46053.1
      UniProtKB/Swiss-Prot
      Q6E0U4
      Related
      ENSP00000388404.2, ENST00000424570.6
    4. NM_001126058.3NP_001119530.2  dermokine isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, compared to variant 2. The resulting isoform (4, also referred to as isoform gamma 1) has a distinct C-terminus and is shorter than isoform 2.
      Source sequence(s)
      AC138125, AY358412, AY789696
      Consensus CDS
      CCDS46052.1
      UniProtKB/Swiss-Prot
      Q6E0U4
      Related
      ENSP00000414743.1, ENST00000418261.5
    5. NM_001126059.4NP_001119531.2  dermokine isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 2. The encoded isoform (6, also referred to as isoform delta) has a distinct N-terminus and is shorter than isoform 2.
      Source sequence(s)
      AD001502
      Consensus CDS
      CCDS46051.1
      Related
      ENSP00000392222.2, ENST00000414866.6
    6. NM_001190347.2NP_001177276.2  dermokine isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate in-frame exon and contains two additional alternate in-frame exons in the coding region, compared to variant 2. This results in a shorter protein (isoform 8, also referred to as isoform beta-1), compared to isoform 2.
      Source sequence(s)
      AC138125, AD001502
      Consensus CDS
      CCDS54250.1
      Related
      ENSP00000405503.1, ENST00000429837.5
    7. NM_001190348.2NP_001177277.1  dermokine isoform 9 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple difference compared to variant 2. This variant encodes isoform 9, which is shorter than isoform 2.
      Source sequence(s)
      AC138125, AY358412, AY789697, EF158326
      Consensus CDS
      CCDS54252.1
      UniProtKB/Swiss-Prot
      Q6E0U4
      UniProtKB/TrEMBL
      A3EZ84
      Related
      ENSP00000394908.2, ENST00000447113.6
    8. NM_001190349.2NP_001177278.1  dermokine isoform 10 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple difference compared to variant 2. This variant encodes isoform 10 (also referred to as isoform gamma 1), which is shorter than isoform 2.
      Source sequence(s)
      AC138125, AY358412, AY789697
      Consensus CDS
      CCDS54251.1
      UniProtKB/Swiss-Prot
      Q6E0U4
      Related
      ENSP00000409513.2, ENST00000451297.6
    9. NM_001308380.2NP_001295309.2  dermokine isoform 11

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and has multiple coding region differences, one of which results in use of an alternate start codon and novel 5' coding region compared to variant 2. It encodes isoform 11, which is shorter than and has a distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AD001502
      Consensus CDS
      CCDS77279.1
      Related
      ENSP00000384509.2, ENST00000402589.6
    10. NM_001308383.2NP_001295312.2  dermokine isoform 12

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and has multiple coding region differences, one of which results in use of an alternate start codon and novel 5' coding region compared to variant 2. It encodes isoform 12, which is shorter than and has a distinct N-terminus compared to isoform 2.
      Source sequence(s)
      AD001502
      Consensus CDS
      CCDS77278.1
      Related
      ENSP00000412075.1, ENST00000436012.5
    11. NM_001352328.2NP_001339257.2  dermokine isoform 13

      Status: REVIEWED

      Source sequence(s)
      AD001502
    12. NM_001352329.2NP_001339258.2  dermokine isoform 14

      Status: REVIEWED

      Source sequence(s)
      AD001502
      Consensus CDS
      CCDS86745.1
      Related
      ENSP00000473341.2, ENST00000472252.6
    13. NM_001352330.2NP_001339259.2  dermokine isoform 14

      Status: REVIEWED

      Source sequence(s)
      AD001502
      Consensus CDS
      CCDS86745.1
    14. NM_001352331.2NP_001339260.1  dermokine isoform 15

      Status: REVIEWED

      Source sequence(s)
      CD174636, CD388805, EF158325
      Consensus CDS
      CCDS86747.1
      Related
      ENSP00000376042.2, ENST00000392206.6
    15. NM_001352332.2NP_001339261.1  dermokine isoform 16

      Status: REVIEWED

      Source sequence(s)
      CD388805
      Consensus CDS
      CCDS86746.1
      Related
      ENSP00000473191.1, ENST00000488892.5
    16. NM_033317.5NP_201574.4  dermokine isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2, also referred to as isoform beta).
      Source sequence(s)
      AC138125, AD001502
      Consensus CDS
      CCDS12463.1
      Related
      ENSP00000342012.3, ENST00000339686.8

    RNA

    1. NR_033746.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs at its 5' end compared to variant 2. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest in-frame ORF compared to variant 2; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AD001502
      Related
      ENST00000462721.5
    2. NR_147958.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      CD173452, EF158325
      Related
      ENST00000480507.1
    3. NR_147959.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AI914430, BI860500, EF158323, EF158325

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      35497217..35513678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527507.2XP_011525809.1  dermokine isoform X12

    2. XM_011527499.2XP_011525801.1  dermokine isoform X4

    3. XM_011527509.2XP_011525811.1  dermokine isoform X14

    4. XM_024451775.1XP_024307543.1  dermokine isoform X14

    5. XM_011527508.2XP_011525810.1  dermokine isoform X13

    6. XM_011527505.2XP_011525807.1  dermokine isoform X10

    7. XM_011527506.2XP_011525808.1  dermokine isoform X11

    8. XM_011527502.2XP_011525804.1  dermokine isoform X7

    9. XM_011527503.2XP_011525805.1  dermokine isoform X8

    10. XM_011527496.2XP_011525798.1  dermokine isoform X2

    11. XM_011527504.2XP_011525806.1  dermokine isoform X9

    12. XM_011527500.2XP_011525802.1  dermokine isoform X5

    13. XM_011527501.2XP_011525803.1  dermokine isoform X6

    14. XM_011527497.2XP_011525799.1  dermokine isoform X3

      See identical proteins and their annotated locations for XP_011525799.1

    15. XM_011527498.2XP_011525800.1  dermokine isoform X3

      See identical proteins and their annotated locations for XP_011525800.1

    16. XM_011527494.2XP_011525796.1  dermokine isoform X1

      See identical proteins and their annotated locations for XP_011525796.1

    17. XM_011527495.2XP_011525797.1  dermokine isoform X1

      See identical proteins and their annotated locations for XP_011525797.1

    18. XM_006723503.3XP_006723566.1  dermokine isoform X20

      See identical proteins and their annotated locations for XP_006723566.1

    19. XM_011527513.1XP_011525815.1  dermokine isoform X18

    20. XM_006723484.1XP_006723547.1  dermokine isoform X16

    21. XM_017027475.1XP_016882964.1  dermokine isoform X17

      Related
      ENSP00000388378.1, ENST00000434389.5
    22. XM_024451776.1XP_024307544.1  dermokine isoform X19

      Related
      ENSP00000471112.1, ENST00000467637.5
    23. XM_006723477.1XP_006723540.1  dermokine isoform X15

      UniProtKB/TrEMBL
      C9IYI1
      Related
      ENSP00000406864.1, ENST00000443640.5
    24. XM_024451779.1XP_024307547.1  dermokine isoform X24

      Related
      ENSP00000474419.1, ENST00000492341.6
    25. XM_024451778.1XP_024307546.1  dermokine isoform X24

    26. XM_024451777.1XP_024307545.1  dermokine isoform X23

    27. XM_006723494.2XP_006723557.1  dermokine isoform X22

      UniProtKB/Swiss-Prot
      Q6E0U4
    28. XM_006723493.2XP_006723556.1  dermokine isoform X21

      UniProtKB/Swiss-Prot
      Q6E0U4
    29. XM_006723489.1XP_006723552.1  dermokine isoform X20

      See identical proteins and their annotated locations for XP_006723552.1

    RNA

    1. XR_935874.2 RNA Sequence

    2. XR_935873.2 RNA Sequence

    3. XR_935872.2 RNA Sequence

    4. XR_935871.2 RNA Sequence

    5. XR_002958384.1 RNA Sequence

    6. XR_002958383.1 RNA Sequence

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